TY - JOUR

T1 - Site-Specific Neuromodulation of Detrusor and External Urethral Sphincter by Epidural Spinal Cord Stimulation

AU - Sysoev, Yuriy

AU - Bazhenova, Elena

AU - Lyakhovetskii, Vsevolod

AU - Kovalev, Gleb

AU - Shkorbatova, Polina

AU - Islamova, Regina

AU - Pavlova, Natalia

AU - Gorskii, Oleg

AU - Merkulyeva, Natalia

AU - Shkarupa, Dmitry

AU - Musienko, Pavel

PY - 2020/7/22

Y1 - 2020/7/22

N2 - Impairments of the lower urinary tract function including urine storage and voiding are widely spread among patients with spinal cord injuries. The management of such patients includes bladder catheterization, surgical and pharmacological approaches, which reduce the morbidity from urinary tract-related complications. However, to date, there is no effective treatment of neurogenic bladder and restoration of urinary function. In the present study, we examined neuromodulation of detrusor (Detr) and external urethral sphincter by epidural electrical stimulation (EES) of lumbar and sacral regions of the spinal cord in chronic rats. To our knowledge, it is the first chronic study where detrusor and external urethral sphincter signals were recorded simultaneously to monitor their neuromodulation by site-specific spinal cord stimulation (SCS). The data obtained demonstrate that activation of detrusor muscle mainly occurs during the stimulation of the upper lumbar (L1) and lower lumbar (L5-L6) spinal segments whereas external urethral sphincter was activated predominantly by sacral stimulation. These findings can be used for the development of neurorehabilitation strategies based on spinal cord epidural stimulation for autonomic function recovery after severe spinal cord injury (SCI).

AB - Impairments of the lower urinary tract function including urine storage and voiding are widely spread among patients with spinal cord injuries. The management of such patients includes bladder catheterization, surgical and pharmacological approaches, which reduce the morbidity from urinary tract-related complications. However, to date, there is no effective treatment of neurogenic bladder and restoration of urinary function. In the present study, we examined neuromodulation of detrusor (Detr) and external urethral sphincter by epidural electrical stimulation (EES) of lumbar and sacral regions of the spinal cord in chronic rats. To our knowledge, it is the first chronic study where detrusor and external urethral sphincter signals were recorded simultaneously to monitor their neuromodulation by site-specific spinal cord stimulation (SCS). The data obtained demonstrate that activation of detrusor muscle mainly occurs during the stimulation of the upper lumbar (L1) and lower lumbar (L5-L6) spinal segments whereas external urethral sphincter was activated predominantly by sacral stimulation. These findings can be used for the development of neurorehabilitation strategies based on spinal cord epidural stimulation for autonomic function recovery after severe spinal cord injury (SCI).

KW - detrusor

KW - epidural spinal cord electrical stimulation

KW - external urethral sphincter

KW - low urinary tract

KW - neuromodulation

KW - MICTURITION

KW - URINARY-BLADDER

KW - MUSCLE

KW - INJURY

KW - LOCOMOTION

KW - IMPROVES BLADDER FUNCTION

KW - CIRCUITS

KW - ELECTRICAL-STIMULATION

KW - PUDENDAL NERVE-STIMULATION

KW - BRAIN

UR - http://www.scopus.com/inward/record.url?scp=85089076889&partnerID=8YFLogxK

U2 - 10.3389/fnsys.2020.00047

DO - 10.3389/fnsys.2020.00047

M3 - Article

AN - SCOPUS:85089076889

VL - 14

JO - Frontiers in Systems Neuroscience

JF - Frontiers in Systems Neuroscience

SN - 1662-5137

M1 - 47

ER -