Seafloor hydrothermal systems and associated sulfide mineralization have been reported along all types of mid-oceanic spreading ridges, island arcs, and back-arc settings. This study reports the occurrence of a distal ridge (∼35 km off-axis) hydrothermal mineralization zone from the slow-spreading Central Indian Ridge (23.19°S) of the Indian Ocean. The hydrothermal precipitates were recovered during dredging operations and mainly comprised of massive sulfides, sulfide breccias, and their secondary oxidized alteration products. The mineralogical quantification of pyrites (significant Cu enrichment, a strong negative correlation with Fe), and bulk sulfide geochemistry (concentrations and ratio of Ba, Co, and Pb) hint at a possible mixed type of mafic-ultramafic host-rock influence in the formation of sulfides. The 230Th/U chronological estimations of pyrites from massive sulfide and sulfide breccia suggest a wide range of hydrothermal activity from 144 ± 11 to 52 ± 7 ka. The AUV-assisted near sea floor sub-bottom profiling (SBP) and High-resolution Interferometric Synthetic Aperture Sonar (HISAS) images suggest that the study area is covered by thin layers of sediments with occasional exposure of hard rock outcrops. The reporting mineralization site stands out to be the most distant and one of the chronologically oldest hydrothermal mineralization zones within the Indian Ocean. The study provides insights into the broader geological processes at off-axis locations concerning the hydrothermal mineralization at slow-spreading ridges and indicates the possibility that such undiscovered buried hydrothermal fields may exist located far from the present-day ridge axis.