The main ingredients of conventional Supersymmetrical Quantum Mechanics (SUSY QM) are presented. The generalization with supercharges of second order in derivatives - Second Order SUSY - is formulated, and the property of shape invariance is defined. The generalization to two-dimensional coordinate space, after using just these two elements of the modern SUSY QM approach, provides the opportunity to solve analytically some two-dimensional problems. Two different procedures of supersymmetrical separation of variables are formulated. They are illustrated by two-dimensional generalization of the Morse model.