TY - JOUR

T1 - Sezonnye izmeneniia v sisteme gamma-aminomaslianoǐ kisloty golovnogo mozga mysheǐ.

AU - Rozanov, V. A.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Dynamics of gamma-aminobutyric acid (GABA) content, the level of glutamate and total content of dicarboxylic amino acids and their amides as well as glutamate decarboxylase and GABA-alpha-ketoglutarate aminotransferase activities in the brain of F1CBAXC57BL/6 hybrid mice were determined during a year. The content of GABA and adicarboxylic acids in the brain in autumn-winter is higher than in summer. An analogous regularity is observed in the activity of basic enzymes of the GABA metabolism. Against a background of the common regularity (higher values of these indices in winter and autumn and comparatively low in summer) a particularly pronounced significant increase (as compared with the minimum level) is found in March for the activity of GABA-shunt enzymes, the content of GABA and dicarboxylic amino acids. The data obtained testify to the fact that in autumn-winter the brain tissue is characterized by a comparatively high content of dicarboxylic amino acids, their amides and GABA as well as by a more intensive functioning of the GABA-shunt, which is confirmed by the activation of the enzymes of GABA production and utilization in the corresponding seasons.

AB - Dynamics of gamma-aminobutyric acid (GABA) content, the level of glutamate and total content of dicarboxylic amino acids and their amides as well as glutamate decarboxylase and GABA-alpha-ketoglutarate aminotransferase activities in the brain of F1CBAXC57BL/6 hybrid mice were determined during a year. The content of GABA and adicarboxylic acids in the brain in autumn-winter is higher than in summer. An analogous regularity is observed in the activity of basic enzymes of the GABA metabolism. Against a background of the common regularity (higher values of these indices in winter and autumn and comparatively low in summer) a particularly pronounced significant increase (as compared with the minimum level) is found in March for the activity of GABA-shunt enzymes, the content of GABA and dicarboxylic amino acids. The data obtained testify to the fact that in autumn-winter the brain tissue is characterized by a comparatively high content of dicarboxylic amino acids, their amides and GABA as well as by a more intensive functioning of the GABA-shunt, which is confirmed by the activation of the enzymes of GABA production and utilization in the corresponding seasons.

UR - http://www.scopus.com/inward/record.url?scp=0020019677&partnerID=8YFLogxK

M3 - статья

C2 - 6120593

AN - SCOPUS:0020019677

VL - 54

SP - 36

EP - 40

JO - Ukrainian biochemical journal

JF - Ukrainian biochemical journal

SN - 2409-4943

IS - 1

ER -