Sexual dimorphism in COVID-19: potential clinical and public health implications

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Sexual dimorphism in COVID-19: potential clinical and public health implications. / Bechmann, Nicole; Barthel, Andreas ; Schedl, Andreas ; Herzig, Stephan ; Varga, Zsuzsanna ; Gebhard, Catherine ; Mayr, Manuel ; Hantel, Constanze ; Beuschlein, Felix ; Wolfrum, Christian ; Perakakis, Nikolaos ; Poston, Lucilla; Andoniadou, Cynthia L ; Siow, Richard ; Gainetdinov, Raul R.; Dotan, Arad ; Shoenfeld, Yehuda; Mingrone, Geltrude; Bornstein, Stefan R. .

In: The Lancet Diabetes and Endocrinology, Vol. 10, No. 3, 03.2022, p. 221-230.

Research output: Contribution to journal › Review article › peer-review

Harvard

Bechmann, N, Barthel, A, Schedl, A, Herzig, S, Varga, Z, Gebhard, C, Mayr, M, Hantel, C, Beuschlein, F, Wolfrum, C, Perakakis, N, Poston, L, Andoniadou, CL, Siow, R, Gainetdinov, RR, Dotan, A, Shoenfeld, Y, Mingrone, G & Bornstein, SR 2022, 'Sexual dimorphism in COVID-19: potential clinical and public health implications', The Lancet Diabetes and Endocrinology, vol. 10, no. 3, pp. 221-230. https://doi.org/10.1016/S2213-8587(21)00346-6

APA

Bechmann, N., Barthel, A., Schedl, A., Herzig, S., Varga, Z., Gebhard, C., Mayr, M., Hantel, C., Beuschlein, F., Wolfrum, C., Perakakis, N., Poston, L., Andoniadou, C. L., Siow, R., Gainetdinov, R. R., Dotan, A., Shoenfeld, Y., Mingrone, G., & Bornstein, S. R. (2022). Sexual dimorphism in COVID-19: potential clinical and public health implications. The Lancet Diabetes and Endocrinology, 10(3), 221-230. https://doi.org/10.1016/S2213-8587(21)00346-6

Vancouver

Bechmann N, Barthel A, Schedl A, Herzig S, Varga Z, Gebhard C et al. Sexual dimorphism in COVID-19: potential clinical and public health implications. The Lancet Diabetes and Endocrinology. 2022 Mar;10(3):221-230. https://doi.org/10.1016/S2213-8587(21)00346-6

Author

Bechmann, Nicole ; Barthel, Andreas ; Schedl, Andreas ; Herzig, Stephan ; Varga, Zsuzsanna ; Gebhard, Catherine ; Mayr, Manuel ; Hantel, Constanze ; Beuschlein, Felix ; Wolfrum, Christian ; Perakakis, Nikolaos ; Poston, Lucilla ; Andoniadou, Cynthia L ; Siow, Richard ; Gainetdinov, Raul R. ; Dotan, Arad ; Shoenfeld, Yehuda ; Mingrone, Geltrude ; Bornstein, Stefan R. . / Sexual dimorphism in COVID-19: potential clinical and public health implications. In: The Lancet Diabetes and Endocrinology. 2022 ; Vol. 10, No. 3. pp. 221-230.

BibTeX

@article{a5bc875cc22c438c9e2070b8e4898401,

title = "Sexual dimorphism in COVID-19: potential clinical and public health implications",

abstract = "Current evidence suggests that severity and mortality of COVID-19 is higher in men than in women, whereas women might be at increased risk of COVID-19 reinfection and development of long COVID. Differences between sexes have been observed in other infectious diseases and in the response to vaccines. Sex-specific expression patterns of proteins mediating virus binding and entry, and divergent reactions of the immune and endocrine system, in particular the hypothalamic–pituitary–adrenal axis, in response to acute stress might explain the higher severity of COVID-19 in men. In this Personal View, we discuss how sex hormones, comorbidities, and the sex chromosome complement influence these mechanisms in the context of COVID-19. Due to its role in the severity and progression of SARS-CoV-2 infections, we argue that sexual dimorphism has potential implications for disease treatment, public health measures, and follow-up of patients predisposed to the development of long COVID. We suggest that sex differences could be considered in future pandemic surveillance and treatment of patients with COVID-19 to help to achieve better disease stratification and improved outcomes.",

keywords = "COVID-19/complications, Female, Health Status Disparities, Humans, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Public Health, Sex Characteristics",

author = "Nicole Bechmann and Andreas Barthel and Andreas Schedl and Stephan Herzig and Zsuzsanna Varga and Catherine Gebhard and Manuel Mayr and Constanze Hantel and Felix Beuschlein and Christian Wolfrum and Nikolaos Perakakis and Lucilla Poston and Andoniadou, {Cynthia L} and Richard Siow and Gainetdinov, {Raul R.} and Arad Dotan and Yehuda Shoenfeld and Geltrude Mingrone and Bornstein, {Stefan R.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = mar,

doi = "10.1016/S2213-8587(21)00346-6",

language = "English",

volume = "10",

pages = "221--230",

journal = "Wine Economics and Policy",

issn = "2213-8587",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - Sexual dimorphism in COVID-19: potential clinical and public health implications

AU - Bechmann, Nicole

AU - Barthel, Andreas

AU - Schedl, Andreas

AU - Herzig, Stephan

AU - Varga, Zsuzsanna

AU - Gebhard, Catherine

AU - Mayr, Manuel

AU - Hantel, Constanze

AU - Beuschlein, Felix

AU - Wolfrum, Christian

AU - Perakakis, Nikolaos

AU - Poston, Lucilla

AU - Andoniadou, Cynthia L

AU - Siow, Richard

AU - Gainetdinov, Raul R.

AU - Dotan, Arad

AU - Shoenfeld, Yehuda

AU - Mingrone, Geltrude

AU - Bornstein, Stefan R.

PY - 2022/3

Y1 - 2022/3

N2 - Current evidence suggests that severity and mortality of COVID-19 is higher in men than in women, whereas women might be at increased risk of COVID-19 reinfection and development of long COVID. Differences between sexes have been observed in other infectious diseases and in the response to vaccines. Sex-specific expression patterns of proteins mediating virus binding and entry, and divergent reactions of the immune and endocrine system, in particular the hypothalamic–pituitary–adrenal axis, in response to acute stress might explain the higher severity of COVID-19 in men. In this Personal View, we discuss how sex hormones, comorbidities, and the sex chromosome complement influence these mechanisms in the context of COVID-19. Due to its role in the severity and progression of SARS-CoV-2 infections, we argue that sexual dimorphism has potential implications for disease treatment, public health measures, and follow-up of patients predisposed to the development of long COVID. We suggest that sex differences could be considered in future pandemic surveillance and treatment of patients with COVID-19 to help to achieve better disease stratification and improved outcomes.

AB - Current evidence suggests that severity and mortality of COVID-19 is higher in men than in women, whereas women might be at increased risk of COVID-19 reinfection and development of long COVID. Differences between sexes have been observed in other infectious diseases and in the response to vaccines. Sex-specific expression patterns of proteins mediating virus binding and entry, and divergent reactions of the immune and endocrine system, in particular the hypothalamic–pituitary–adrenal axis, in response to acute stress might explain the higher severity of COVID-19 in men. In this Personal View, we discuss how sex hormones, comorbidities, and the sex chromosome complement influence these mechanisms in the context of COVID-19. Due to its role in the severity and progression of SARS-CoV-2 infections, we argue that sexual dimorphism has potential implications for disease treatment, public health measures, and follow-up of patients predisposed to the development of long COVID. We suggest that sex differences could be considered in future pandemic surveillance and treatment of patients with COVID-19 to help to achieve better disease stratification and improved outcomes.

KW - COVID-19/complications

KW - Female

KW - Health Status Disparities

KW - Humans

KW - Hypothalamo-Hypophyseal System

KW - Male

KW - Pituitary-Adrenal System

KW - Public Health

KW - Sex Characteristics

UR - http://www.scopus.com/inward/record.url?scp=85125289240&partnerID=8YFLogxK

U2 - 10.1016/S2213-8587(21)00346-6

DO - 10.1016/S2213-8587(21)00346-6

M3 - Review article

C2 - 35114136

VL - 10

SP - 221

EP - 230

JO - Wine Economics and Policy

JF - Wine Economics and Policy

SN - 2213-8587

IS - 3

ER -

ID: 100361002