Sex differences in behavior and neuropharmacology of zebrafish

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Sex differences in behavior and neuropharmacology of zebrafish. / Genario, Rafael; de Abreu, Murilo S.; Giacomini, Ana C.V.V.; Demin, Konstantin A.; Kalueff, Allan V.

In: European Journal of Neuroscience, 28.06.2019.

Research output: Contribution to journal › Review article › peer-review

Author

Genario, Rafael ; de Abreu, Murilo S. ; Giacomini, Ana C.V.V. ; Demin, Konstantin A. ; Kalueff, Allan V. / Sex differences in behavior and neuropharmacology of zebrafish. In: European Journal of Neuroscience. 2019.

BibTeX

@article{b9a8e4ed101e4af59e4da940ffe1a5f0,

title = "Sex differences in behavior and neuropharmacology of zebrafish",

abstract = "Sex is an important variable in biomedical research. The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in translational neuroscience and pharmacology. Mounting evidence indicates important sex differences in zebrafish behavioral and neuropharmacological responses. Here, we discuss the role of sex in zebrafish central nervous system (CNS) models, their molecular mechanisms, recent findings and the existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of sex differences, fostering future CNS drug discovery and the search for novel sex-specific therapies. Finally, we highlight the interplay between sex and environment in zebrafish models of sex-environment correlations as an important strategy of CNS disease modeling using this aquatic organism.",

keywords = "CNS diseases, gender differences, pharmacogenetics, sex-environment interactions",

author = "Rafael Genario and {de Abreu}, {Murilo S.} and Giacomini, {Ana C.V.V.} and Demin, {Konstantin A.} and Kalueff, {Allan V.}",

note = "Genario, R., de Abreu, M. S., Giacomini, A. C. V. V., Demin, K. A., & Kalueff, A. V. (2019). Sex differences in behavior and neuropharmacology of zebrafish. European Journal of Neuroscience. Blackwell Publishing Ltd. https://doi.org/10.1111/ejn.14438",

year = "2019",

month = jun,

day = "28",

doi = "10.1111/ejn.14438",

language = "English",

journal = "European Journal of Neuroscience",

issn = "0953-816X",

publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Sex differences in behavior and neuropharmacology of zebrafish

AU - Genario, Rafael

AU - de Abreu, Murilo S.

AU - Giacomini, Ana C.V.V.

AU - Demin, Konstantin A.

AU - Kalueff, Allan V.

N1 - Genario, R., de Abreu, M. S., Giacomini, A. C. V. V., Demin, K. A., & Kalueff, A. V. (2019). Sex differences in behavior and neuropharmacology of zebrafish. European Journal of Neuroscience. Blackwell Publishing Ltd. https://doi.org/10.1111/ejn.14438

PY - 2019/6/28

Y1 - 2019/6/28

N2 - Sex is an important variable in biomedical research. The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in translational neuroscience and pharmacology. Mounting evidence indicates important sex differences in zebrafish behavioral and neuropharmacological responses. Here, we discuss the role of sex in zebrafish central nervous system (CNS) models, their molecular mechanisms, recent findings and the existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of sex differences, fostering future CNS drug discovery and the search for novel sex-specific therapies. Finally, we highlight the interplay between sex and environment in zebrafish models of sex-environment correlations as an important strategy of CNS disease modeling using this aquatic organism.

AB - Sex is an important variable in biomedical research. The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in translational neuroscience and pharmacology. Mounting evidence indicates important sex differences in zebrafish behavioral and neuropharmacological responses. Here, we discuss the role of sex in zebrafish central nervous system (CNS) models, their molecular mechanisms, recent findings and the existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of sex differences, fostering future CNS drug discovery and the search for novel sex-specific therapies. Finally, we highlight the interplay between sex and environment in zebrafish models of sex-environment correlations as an important strategy of CNS disease modeling using this aquatic organism.

KW - CNS diseases

KW - gender differences

KW - pharmacogenetics

KW - sex-environment interactions

UR - http://www.scopus.com/inward/record.url?scp=85068314187&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/sex-differences-behavior-neuropharmacology-zebrafish

U2 - 10.1111/ejn.14438

DO - 10.1111/ejn.14438

M3 - Review article

C2 - 31090957

AN - SCOPUS:85068314187

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

ER -

ID: 45074917