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Serotonin limits generation of chromaffin cells during adrenal organ development. / Kameneva, Polina ; Melnikova, Victoria I. ; Kastriti, Maria Eleni ; Kurtova, Anastasia ; Kryukov, Emil ; Murtazina, Aliia ; Faure, Louis ; Poverennaya, Irina ; Artemov, Artem V. ; Kalinina, Tatiana S. ; Kudryashov, Nikita V. ; Bader, Michael; Skoda , Jan ; Chlapek, Petr ; Curylova, Lucie ; Sourada, Lukas ; Neradil , Jakub ; Tesarova, Marketa ; Pasqualetti , Massimo ; Gaspar, Patricia; Yakushov, Vasily D. ; Sheftel, Boris I. ; Zikmund, Tomas ; Kaiser, Jozef ; Fried, Kaj; Alenina, Natalia ; Voronezhskaya, Elena E.; Adameyko, Igor.

In: Nature Communications, Vol. 13, No. 1, 2901, 12.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Kameneva, P, Melnikova, VI, Kastriti, ME, Kurtova, A, Kryukov, E, Murtazina, A, Faure, L, Poverennaya, I, Artemov, AV, Kalinina, TS, Kudryashov, NV, Bader, M, Skoda , J, Chlapek, P, Curylova, L, Sourada, L, Neradil , J, Tesarova, M, Pasqualetti , M, Gaspar, P, Yakushov, VD, Sheftel, BI, Zikmund, T, Kaiser, J, Fried, K, Alenina, N, Voronezhskaya, EE & Adameyko, I 2022, 'Serotonin limits generation of chromaffin cells during adrenal organ development', Nature Communications, vol. 13, no. 1, 2901. https://doi.org/10.1038/s41467-022-30438-w

APA

Kameneva, P., Melnikova, V. I., Kastriti, M. E., Kurtova, A., Kryukov, E., Murtazina, A., Faure, L., Poverennaya, I., Artemov, A. V., Kalinina, T. S., Kudryashov, N. V., Bader, M., Skoda , J., Chlapek, P., Curylova, L., Sourada, L., Neradil , J., Tesarova, M., Pasqualetti , M., ... Adameyko, I. (2022). Serotonin limits generation of chromaffin cells during adrenal organ development. Nature Communications, 13(1), [2901]. https://doi.org/10.1038/s41467-022-30438-w

Vancouver

Kameneva P, Melnikova VI, Kastriti ME, Kurtova A, Kryukov E, Murtazina A et al. Serotonin limits generation of chromaffin cells during adrenal organ development. Nature Communications. 2022 Dec;13(1). 2901. https://doi.org/10.1038/s41467-022-30438-w

Author

Kameneva, Polina ; Melnikova, Victoria I. ; Kastriti, Maria Eleni ; Kurtova, Anastasia ; Kryukov, Emil ; Murtazina, Aliia ; Faure, Louis ; Poverennaya, Irina ; Artemov, Artem V. ; Kalinina, Tatiana S. ; Kudryashov, Nikita V. ; Bader, Michael ; Skoda , Jan ; Chlapek, Petr ; Curylova, Lucie ; Sourada, Lukas ; Neradil , Jakub ; Tesarova, Marketa ; Pasqualetti , Massimo ; Gaspar, Patricia ; Yakushov, Vasily D. ; Sheftel, Boris I. ; Zikmund, Tomas ; Kaiser, Jozef ; Fried, Kaj ; Alenina, Natalia ; Voronezhskaya, Elena E. ; Adameyko, Igor. / Serotonin limits generation of chromaffin cells during adrenal organ development. In: Nature Communications. 2022 ; Vol. 13, No. 1.

BibTeX

@article{38cfb399d9aa4e19a5dde2e2c3a84f8e,
title = "Serotonin limits generation of chromaffin cells during adrenal organ development",
abstract = "Adrenal glands are the major organs releasing catecholamines and regulating our stress response. The mechanisms balancing generation of adrenergic chromaffin cells and protecting against neuroblastoma tumors are still enigmatic. Here we revealed that serotonin (5HT) controls the numbers of chromaffin cells by acting upon their immediate progenitor {"}bridge{"} cells via 5-hydroxytryptamine receptor 3A (HTR3A), and the aggressive HTR3Ahigh human neuroblastoma cell lines reduce proliferation in response to HTR3A-specific agonists. In embryos (in vivo), the physiological increase of 5HT caused a prolongation of the cell cycle in {"}bridge{"} progenitors leading to a smaller chromaffin population and changing the balance of hormones and behavioral patterns in adulthood. These behavioral effects and smaller adrenals were mirrored in the progeny of pregnant female mice subjected to experimental stress, suggesting a maternal-fetal link that controls developmental adaptations. Finally, these results corresponded to a size-distribution of adrenals found in wild rodents with different coping strategies.",
keywords = "Adrenal Glands/metabolism, Animals, Catecholamines/metabolism, Chromaffin Cells/metabolism, Female, Mice, Neuroblastoma/metabolism, Pregnancy, Serotonin/metabolism",
author = "Polina Kameneva and Melnikova, {Victoria I.} and Kastriti, {Maria Eleni} and Anastasia Kurtova and Emil Kryukov and Aliia Murtazina and Louis Faure and Irina Poverennaya and Artemov, {Artem V.} and Kalinina, {Tatiana S.} and Kudryashov, {Nikita V.} and Michael Bader and Jan Skoda and Petr Chlapek and Lucie Curylova and Lukas Sourada and Jakub Neradil and Marketa Tesarova and Massimo Pasqualetti and Patricia Gaspar and Yakushov, {Vasily D.} and Sheftel, {Boris I.} and Tomas Zikmund and Jozef Kaiser and Kaj Fried and Natalia Alenina and Voronezhskaya, {Elena E.} and Igor Adameyko",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41467-022-30438-w",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Serotonin limits generation of chromaffin cells during adrenal organ development

AU - Kameneva, Polina

AU - Melnikova, Victoria I.

AU - Kastriti, Maria Eleni

AU - Kurtova, Anastasia

AU - Kryukov, Emil

AU - Murtazina, Aliia

AU - Faure, Louis

AU - Poverennaya, Irina

AU - Artemov, Artem V.

AU - Kalinina, Tatiana S.

AU - Kudryashov, Nikita V.

AU - Bader, Michael

AU - Skoda , Jan

AU - Chlapek, Petr

AU - Curylova, Lucie

AU - Sourada, Lukas

AU - Neradil , Jakub

AU - Tesarova, Marketa

AU - Pasqualetti , Massimo

AU - Gaspar, Patricia

AU - Yakushov, Vasily D.

AU - Sheftel, Boris I.

AU - Zikmund, Tomas

AU - Kaiser, Jozef

AU - Fried, Kaj

AU - Alenina, Natalia

AU - Voronezhskaya, Elena E.

AU - Adameyko, Igor

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Adrenal glands are the major organs releasing catecholamines and regulating our stress response. The mechanisms balancing generation of adrenergic chromaffin cells and protecting against neuroblastoma tumors are still enigmatic. Here we revealed that serotonin (5HT) controls the numbers of chromaffin cells by acting upon their immediate progenitor "bridge" cells via 5-hydroxytryptamine receptor 3A (HTR3A), and the aggressive HTR3Ahigh human neuroblastoma cell lines reduce proliferation in response to HTR3A-specific agonists. In embryos (in vivo), the physiological increase of 5HT caused a prolongation of the cell cycle in "bridge" progenitors leading to a smaller chromaffin population and changing the balance of hormones and behavioral patterns in adulthood. These behavioral effects and smaller adrenals were mirrored in the progeny of pregnant female mice subjected to experimental stress, suggesting a maternal-fetal link that controls developmental adaptations. Finally, these results corresponded to a size-distribution of adrenals found in wild rodents with different coping strategies.

AB - Adrenal glands are the major organs releasing catecholamines and regulating our stress response. The mechanisms balancing generation of adrenergic chromaffin cells and protecting against neuroblastoma tumors are still enigmatic. Here we revealed that serotonin (5HT) controls the numbers of chromaffin cells by acting upon their immediate progenitor "bridge" cells via 5-hydroxytryptamine receptor 3A (HTR3A), and the aggressive HTR3Ahigh human neuroblastoma cell lines reduce proliferation in response to HTR3A-specific agonists. In embryos (in vivo), the physiological increase of 5HT caused a prolongation of the cell cycle in "bridge" progenitors leading to a smaller chromaffin population and changing the balance of hormones and behavioral patterns in adulthood. These behavioral effects and smaller adrenals were mirrored in the progeny of pregnant female mice subjected to experimental stress, suggesting a maternal-fetal link that controls developmental adaptations. Finally, these results corresponded to a size-distribution of adrenals found in wild rodents with different coping strategies.

KW - Adrenal Glands/metabolism

KW - Animals

KW - Catecholamines/metabolism

KW - Chromaffin Cells/metabolism

KW - Female

KW - Mice

KW - Neuroblastoma/metabolism

KW - Pregnancy

KW - Serotonin/metabolism

UR - https://www.ceitec.eu/serotonin-limits-generation-of-chromaffin-cells-during-adrenal-organ-development/p123988

UR - https://www.nature.com/articles/s41467-022-30438-w

UR - https://pubmed.ncbi.nlm.nih.gov/35614045/

UR - http://www.scopus.com/inward/record.url?scp=85130751349&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/e27bf234-1a2c-36e5-a8ed-c6c51ae9683b/

U2 - 10.1038/s41467-022-30438-w

DO - 10.1038/s41467-022-30438-w

M3 - Article

C2 - 35614045

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 2901

ER -

ID: 100672703