TY - JOUR

T1 - Secretion of proinflammatory cytokines by villous chrorion tissue in spontaneous abortion

AU - Pavlov, O. V.

AU - Sel'kov, S. A.

AU - Lalayan, D. V.

AU - Arzhanova, O. N.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Secretion of proinflammatory cytokines IL-1βp, TNF-α, IL-6, IFN-α, and IFN-γ by the chorion tissue (8-12 weeks) was studied in normal gestation and spontaneous abortion. The production of IL-1β, TNF-α, and IFN-α virtually did not change in spontaneous abortion, while IFN-γ was not secreted in all experimental groups. The production of IL-6 increased more than 2-fold in patients with spontaneous abortion during the first trimester. These data confirm the involvement of this cytokine in the reproductive processes and in the pathogenesis of miscarriage.

AB - Secretion of proinflammatory cytokines IL-1βp, TNF-α, IL-6, IFN-α, and IFN-γ by the chorion tissue (8-12 weeks) was studied in normal gestation and spontaneous abortion. The production of IL-1β, TNF-α, and IFN-α virtually did not change in spontaneous abortion, while IFN-γ was not secreted in all experimental groups. The production of IL-6 increased more than 2-fold in patients with spontaneous abortion during the first trimester. These data confirm the involvement of this cytokine in the reproductive processes and in the pathogenesis of miscarriage.

KW - Cytokines

KW - Interleukin-6

KW - Spontaneous abortion

KW - Tissue culture

KW - Villous chorion

UR - http://www.scopus.com/inward/record.url?scp=0141705503&partnerID=8YFLogxK

U2 - 10.1023/A:1024621100429

DO - 10.1023/A:1024621100429

M3 - Article

C2 - 12910313

AN - SCOPUS:0141705503

VL - 135

SP - 377

EP - 379

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 4

ER -