Human capital in a post-industrial society is becoming the main condition for the development of society and this is facilitated by the creation in Russia of scientific and educational centers (SECs). The main objectives of the activities of such centers are to enhance the economic and social life in the regions. Large funds are allocated to solve this problem. Therefore, the practical relevance of the sociological monitoring of SECs should be considered as a necessary condition for providing feedback on the effectiveness of SECs in the region. This is not only an important practical task, but also an urgent task of scientific support for the implementation of such monitoring. The article conceptualizes the main elements of the sociological monitoring system of SECs. They relate to the methodology and methodology of the sociological monitoring of SECs. Shown: the relevance of monitoring, its main goals and objectives, the principles of organization of work are indicated. It is important that monitoring is carried out systematically, taking into account information that reveals a combination of objective and subjective indicators characterizing the state of the region’s human potential. The importance of organizing sociological monitoring of the SEC at a value level and using network research technologies is emphasized. The article provides a review of scientific sources that have been devoted to studies of human capital and the history of the problem. An analysis of the historical and modern experience of Russia shows that the unification of science, education and production is the basis of the conceptual model of stimulating the human capital of Russians and ensuring Russia’s competitiveness in the world. It is concluded that the concept of sociological monitoring of the SEC as a factor in the activation of human capital is promising.