Abstract: The importance of controlling total ozone (TO) and surface ultraviolet irradiance is a reason for continuous monitoring of the ozonosphere using various ground-based and satellite methods and instruments. The global monitoring of TO has been carried out with the Russian instrument IKFS-2 on the Meteor-M No. 2 satellite since 2015. These measurements are conducted during the whole day and in polar night conditions. The developed algorithm based on using artificial neural networks and OMI satellite instrument measurements is periodically updated and allows determining TO with an average total error of 3–5%. The IKFS-2 measurements can be used for analyzing spatial and temporal (seasonal, interannual) variations in ozone, its long-term trends, verifying modern numerical stratospheric models, studying ozone anomalies, etc. The examples of analyzing TO in autumn-spring periods and TO anomalies in winter and spring of 2020 are given. They clearly demonstrate advantages of satellite TO measurements with the thermal radiation method.