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Role of Dopamine Transporters in Neuronal Homeostasis. / Caron, Marc G.; Gainetdinov, Raul R.

Dopamine Handbook. Oxford University Press, 2009. p. 88-99.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Harvard

Caron, MG & Gainetdinov, RR 2009, Role of Dopamine Transporters in Neuronal Homeostasis. in Dopamine Handbook. Oxford University Press, pp. 88-99. https://doi.org/10.1093/acprof:oso/9780195373035.003.0007, https://doi.org/10.1093/acprof:oso/9780195373035.001.0001

APA

Caron, M. G., & Gainetdinov, R. R. (2009). Role of Dopamine Transporters in Neuronal Homeostasis. In Dopamine Handbook (pp. 88-99). Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195373035.003.0007, https://doi.org/10.1093/acprof:oso/9780195373035.001.0001

Vancouver

Caron MG, Gainetdinov RR. Role of Dopamine Transporters in Neuronal Homeostasis. In Dopamine Handbook. Oxford University Press. 2009. p. 88-99 https://doi.org/10.1093/acprof:oso/9780195373035.003.0007, https://doi.org/10.1093/acprof:oso/9780195373035.001.0001

Author

Caron, Marc G. ; Gainetdinov, Raul R. / Role of Dopamine Transporters in Neuronal Homeostasis. Dopamine Handbook. Oxford University Press, 2009. pp. 88-99

BibTeX

@inbook{7414ab175a604762870f7a24d2acee4e,
title = "Role of Dopamine Transporters in Neuronal Homeostasis",
abstract = "Dopamine (DA) neurotransmission is controlled by several critical processes. A complex homeostatic balance between the amount of DA synthesized, packaged into vesicles, released, reuptaken via plasma membrane transporter and metabolized, determines the overall status of dopaminergic signaling. The plasma membrane dopamine transporter (DAT) provides effective control of both the extracellular and intracellular concentrations of DA by recapturing released neurotransmitters in the presynaptic terminals. The vesicular monoamine transporter 2 (VMAT2) directly controls vesicular storage and release capacity by pumping monoamines from the cytoplasm of neurons into synaptic vesicles. These transporters are primary targets of many psychotropic drugs that potently affect synaptic DA and related physiological processes. This chapter summarizes recent advances in the understanding of the molecular and cellular mechanisms involved in the DAT and VMAT2 functions. It discusses the role of these transporters in the action of psychostimulant drugs and neurotoxins, as revealed in studies using mutant mice.",
keywords = "DA homeostasis, Dopamine neurotransmission, Dopamine transporter, Vesicular monoamine transporter 2",
author = "Caron, {Marc G.} and Gainetdinov, {Raul R.}",
year = "2009",
doi = "10.1093/acprof:oso/9780195373035.003.0007",
language = "English",
isbn = "9780195373035",
pages = "88--99",
booktitle = "Dopamine Handbook",
publisher = "Oxford University Press",
address = "United Kingdom",

}

RIS

TY - CHAP

T1 - Role of Dopamine Transporters in Neuronal Homeostasis

AU - Caron, Marc G.

AU - Gainetdinov, Raul R.

PY - 2009

Y1 - 2009

N2 - Dopamine (DA) neurotransmission is controlled by several critical processes. A complex homeostatic balance between the amount of DA synthesized, packaged into vesicles, released, reuptaken via plasma membrane transporter and metabolized, determines the overall status of dopaminergic signaling. The plasma membrane dopamine transporter (DAT) provides effective control of both the extracellular and intracellular concentrations of DA by recapturing released neurotransmitters in the presynaptic terminals. The vesicular monoamine transporter 2 (VMAT2) directly controls vesicular storage and release capacity by pumping monoamines from the cytoplasm of neurons into synaptic vesicles. These transporters are primary targets of many psychotropic drugs that potently affect synaptic DA and related physiological processes. This chapter summarizes recent advances in the understanding of the molecular and cellular mechanisms involved in the DAT and VMAT2 functions. It discusses the role of these transporters in the action of psychostimulant drugs and neurotoxins, as revealed in studies using mutant mice.

AB - Dopamine (DA) neurotransmission is controlled by several critical processes. A complex homeostatic balance between the amount of DA synthesized, packaged into vesicles, released, reuptaken via plasma membrane transporter and metabolized, determines the overall status of dopaminergic signaling. The plasma membrane dopamine transporter (DAT) provides effective control of both the extracellular and intracellular concentrations of DA by recapturing released neurotransmitters in the presynaptic terminals. The vesicular monoamine transporter 2 (VMAT2) directly controls vesicular storage and release capacity by pumping monoamines from the cytoplasm of neurons into synaptic vesicles. These transporters are primary targets of many psychotropic drugs that potently affect synaptic DA and related physiological processes. This chapter summarizes recent advances in the understanding of the molecular and cellular mechanisms involved in the DAT and VMAT2 functions. It discusses the role of these transporters in the action of psychostimulant drugs and neurotoxins, as revealed in studies using mutant mice.

KW - DA homeostasis

KW - Dopamine neurotransmission

KW - Dopamine transporter

KW - Vesicular monoamine transporter 2

UR - http://www.scopus.com/inward/record.url?scp=79151485279&partnerID=8YFLogxK

U2 - 10.1093/acprof:oso/9780195373035.003.0007

DO - 10.1093/acprof:oso/9780195373035.003.0007

M3 - Chapter

SN - 9780195373035

SP - 88

EP - 99

BT - Dopamine Handbook

PB - Oxford University Press

ER -

ID: 4617221