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RNA polymerase III transcription machinery : Structure and transcription regulation. / Nikitina, T. V.; Tishchenko, L. I.

In: Molecular Biology, Vol. 39, No. 2, 01.03.2005, p. 161-172.

Research output: Contribution to journal › Review article › peer-review

Harvard

Nikitina, TV & Tishchenko, LI 2005, 'RNA polymerase III transcription machinery: Structure and transcription regulation', Molecular Biology, vol. 39, no. 2, pp. 161-172. https://doi.org/10.1007/s11008-005-0024-x

APA

Nikitina, T. V., & Tishchenko, L. I. (2005). RNA polymerase III transcription machinery: Structure and transcription regulation. Molecular Biology, 39(2), 161-172. https://doi.org/10.1007/s11008-005-0024-x

Vancouver

Nikitina TV, Tishchenko LI. RNA polymerase III transcription machinery: Structure and transcription regulation. Molecular Biology. 2005 Mar 1;39(2):161-172. https://doi.org/10.1007/s11008-005-0024-x

Author

Nikitina, T. V. ; Tishchenko, L. I. / RNA polymerase III transcription machinery : Structure and transcription regulation. In: Molecular Biology. 2005 ; Vol. 39, No. 2. pp. 161-172.

BibTeX

@article{127b9f63f59d490697e47c27e7057b1d,
title = "RNA polymerase III transcription machinery: Structure and transcription regulation",
abstract = "RNA polymerase (Pol) III is a complex multisubunit enzyme that transcribes genes for small stable untranslated RNAs (tRNAs, 5S rRNA, Alu RNA, U6 snRNA) and some other genes (class III genes). Of all eukaryotic Pols, Pol III is the most poorly studied. Recent attention to Pol III is explained by new data on the important role of its RNA products in cell growth, proliferation, and differentiation. The contents of these RNA products depend on the growth rate, the cell-cycle phase, and the physiological state of the cell (slow or active proliferation or apoptosis) and change upon malignant transformation, viral infection, and heat shock. This review considers the structures and functions of Pol III, its basal transcription factors, and the holoenzyme; assembly of the preinitiation complex; and the transcription cycle. In addition, transcriptional regulation of class III genes is described as dependent on the cell cycle phase, growth factors, cell growth rate, transformation, and apoptosis.",
keywords = "Basal transcription factors, Class III genes, Promoters, RNA polymerase III, Transcription regulation",
author = "Nikitina, {T. V.} and Tishchenko, {L. I.}",
year = "2005",
month = mar,
day = "1",
doi = "10.1007/s11008-005-0024-x",
language = "English",
volume = "39",
pages = "161--172",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Pleiades Publishing",
number = "2",

}

RIS

TY - JOUR

T1 - RNA polymerase III transcription machinery

T2 - Structure and transcription regulation

AU - Nikitina, T. V.

AU - Tishchenko, L. I.

PY - 2005/3/1

Y1 - 2005/3/1

N2 - RNA polymerase (Pol) III is a complex multisubunit enzyme that transcribes genes for small stable untranslated RNAs (tRNAs, 5S rRNA, Alu RNA, U6 snRNA) and some other genes (class III genes). Of all eukaryotic Pols, Pol III is the most poorly studied. Recent attention to Pol III is explained by new data on the important role of its RNA products in cell growth, proliferation, and differentiation. The contents of these RNA products depend on the growth rate, the cell-cycle phase, and the physiological state of the cell (slow or active proliferation or apoptosis) and change upon malignant transformation, viral infection, and heat shock. This review considers the structures and functions of Pol III, its basal transcription factors, and the holoenzyme; assembly of the preinitiation complex; and the transcription cycle. In addition, transcriptional regulation of class III genes is described as dependent on the cell cycle phase, growth factors, cell growth rate, transformation, and apoptosis.

AB - RNA polymerase (Pol) III is a complex multisubunit enzyme that transcribes genes for small stable untranslated RNAs (tRNAs, 5S rRNA, Alu RNA, U6 snRNA) and some other genes (class III genes). Of all eukaryotic Pols, Pol III is the most poorly studied. Recent attention to Pol III is explained by new data on the important role of its RNA products in cell growth, proliferation, and differentiation. The contents of these RNA products depend on the growth rate, the cell-cycle phase, and the physiological state of the cell (slow or active proliferation or apoptosis) and change upon malignant transformation, viral infection, and heat shock. This review considers the structures and functions of Pol III, its basal transcription factors, and the holoenzyme; assembly of the preinitiation complex; and the transcription cycle. In addition, transcriptional regulation of class III genes is described as dependent on the cell cycle phase, growth factors, cell growth rate, transformation, and apoptosis.

KW - Basal transcription factors

KW - Class III genes

KW - Promoters

KW - RNA polymerase III

KW - Transcription regulation

UR - http://www.scopus.com/inward/record.url?scp=18844446125&partnerID=8YFLogxK

U2 - 10.1007/s11008-005-0024-x

DO - 10.1007/s11008-005-0024-x

M3 - Review article

AN - SCOPUS:18844446125

VL - 39

SP - 161

EP - 172

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 2

ER -

ID: 53111193