Research output: Contribution to journal › Article › peer-review
An effective method for the synthesis of fully substituted 5-sulfonamidoimidazoles by Rh(II)-catalyzed transannulation of 1,2,4-oxadiazole derivatives with N-sulfonyl-1,2,3-triazoles is reported. The reaction works well with both aromatic 1,2,4-oxadiazoles and 1,2,4-oxadiazol-5-ones providing a flexible approach to N-(alkoxy/amino)carbonyl- and N-alkyl-substituted imidazoles. Both the disclosed reactions are completely regioselective and provide the first examples of a carbenoid-mediated transformation of N,N,O-heterocycles.
Original language | English |
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Pages (from-to) | 11232-11244 |
Number of pages | 13 |
Journal | Journal of Organic Chemistry |
Volume | 83 |
Issue number | 18 |
DOIs | |
State | Published - 21 Sep 2018 |
ID: 35263604