Research output: Contribution to journal › Article › peer-review
Rh(II)-catalyzed condensation of 3-diazotetramic acids with nitriles delivers novel druglike 5,6-dihydro-4H-pyrrolo[3,4-d]oxazol-4-ones. / Кривовичева, Василиса Сергеевна; Кантин, Григорий Павлович; Дарьин, Дмитрий Викторович; Красавин, Михаил Юрьевич.
In: Tetrahedron Letters, Vol. 120, 154457, 28.04.2023.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Rh(II)-catalyzed condensation of 3-diazotetramic acids with nitriles delivers novel druglike 5,6-dihydro-4H-pyrrolo[3,4-d]oxazol-4-ones
AU - Кривовичева, Василиса Сергеевна
AU - Кантин, Григорий Павлович
AU - Дарьин, Дмитрий Викторович
AU - Красавин, Михаил Юрьевич
PY - 2023/4/28
Y1 - 2023/4/28
N2 - Previously reported 3-diazotetramic acids have been successfully involved in Rh(II)-catalyzed condensation with aliphatic and aromatic nitriles delivering compounds bearing a hitherto unexplored polysubstituted fused oxazole scaffold. The latter was found to be somewhat labile to the addition of nucleophiles (water and benzylamine) which leads to oxazole ring opening and may constitute an entry into polysubstituted pyrrolinones after due investigation of scope.
AB - Previously reported 3-diazotetramic acids have been successfully involved in Rh(II)-catalyzed condensation with aliphatic and aromatic nitriles delivering compounds bearing a hitherto unexplored polysubstituted fused oxazole scaffold. The latter was found to be somewhat labile to the addition of nucleophiles (water and benzylamine) which leads to oxazole ring opening and may constitute an entry into polysubstituted pyrrolinones after due investigation of scope.
U2 - 10.1016/j.tetlet.2023.154457
DO - 10.1016/j.tetlet.2023.154457
M3 - Article
VL - 120
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
M1 - 154457
ER -
ID: 113686155