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Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells. / Suvorova, Irina I; Knyazeva, Aleksandra R; Pospelov, Valery A.

In: Biochemical and Biophysical Research Communications, Vol. 503, No. 3, 10.09.2018, p. 2180-2185.

Research output: Contribution to journal › Article › peer-review

Harvard

Suvorova, II, Knyazeva, AR & Pospelov, VA 2018, 'Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells', Biochemical and Biophysical Research Communications, vol. 503, no. 3, pp. 2180-2185. https://doi.org/10.1016/j.bbrc.2018.08.010

APA

Suvorova, I. I., Knyazeva, A. R., & Pospelov, V. A. (2018). Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells. Biochemical and Biophysical Research Communications, 503(3), 2180-2185. https://doi.org/10.1016/j.bbrc.2018.08.010

Vancouver

Suvorova II, Knyazeva AR, Pospelov VA. Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells. Biochemical and Biophysical Research Communications. 2018 Sep 10;503(3):2180-2185. https://doi.org/10.1016/j.bbrc.2018.08.010

Author

Suvorova, Irina I ; Knyazeva, Aleksandra R ; Pospelov, Valery A. / Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells. In: Biochemical and Biophysical Research Communications. 2018 ; Vol. 503, No. 3. pp. 2180-2185.

BibTeX

@article{d5c4ee058204401a8ecdbbe58f600478,
title = "Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells",
abstract = "Resveratrol is a natural polyphenol with several therapeutic effects, in particular, inducing p53-dependent cell cycle arrest and/or apoptosis in tumor cells. Resveratrol-induced p53 activation may trigger differentiation and apoptosis in embryonic stem cells (ESCs). We show that resveratrol activates p53 that is negatively regulated by SIRT1 deacetylation on Lys379 and positively by AMPK phosphorylation on Ser15 in mouse ESCs (mESCs). Surprisingly, the resveratrol-activated p53 is not associated with either G1/S cell cycle checkpoint or apoptosis in mESCs. Instead, it stimulates autophagy in a transcriptional-dependent manner involving up-regulation of dram1 gene expression. This study demonstrates a novel mechanism of resveratrol-dependent p53 activation in mESCs.",
keywords = "Animals, Autophagy/drug effects, Cell Cycle Checkpoints/drug effects, Cells, Cultured, Membrane Proteins/genetics, Mice, Mouse Embryonic Stem Cells/cytology, Resveratrol/pharmacology, Tumor Suppressor Protein p53/agonists, Up-Regulation/drug effects",
author = "Suvorova, {Irina I} and Knyazeva, {Aleksandra R} and Pospelov, {Valery A}",
note = "Published by Elsevier Inc.",
year = "2018",
month = sep,
day = "10",
doi = "10.1016/j.bbrc.2018.08.010",
language = "English",
volume = "503",
pages = "2180--2185",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells

AU - Suvorova, Irina I

AU - Knyazeva, Aleksandra R

AU - Pospelov, Valery A

N1 - Published by Elsevier Inc.

PY - 2018/9/10

Y1 - 2018/9/10

N2 - Resveratrol is a natural polyphenol with several therapeutic effects, in particular, inducing p53-dependent cell cycle arrest and/or apoptosis in tumor cells. Resveratrol-induced p53 activation may trigger differentiation and apoptosis in embryonic stem cells (ESCs). We show that resveratrol activates p53 that is negatively regulated by SIRT1 deacetylation on Lys379 and positively by AMPK phosphorylation on Ser15 in mouse ESCs (mESCs). Surprisingly, the resveratrol-activated p53 is not associated with either G1/S cell cycle checkpoint or apoptosis in mESCs. Instead, it stimulates autophagy in a transcriptional-dependent manner involving up-regulation of dram1 gene expression. This study demonstrates a novel mechanism of resveratrol-dependent p53 activation in mESCs.

AB - Resveratrol is a natural polyphenol with several therapeutic effects, in particular, inducing p53-dependent cell cycle arrest and/or apoptosis in tumor cells. Resveratrol-induced p53 activation may trigger differentiation and apoptosis in embryonic stem cells (ESCs). We show that resveratrol activates p53 that is negatively regulated by SIRT1 deacetylation on Lys379 and positively by AMPK phosphorylation on Ser15 in mouse ESCs (mESCs). Surprisingly, the resveratrol-activated p53 is not associated with either G1/S cell cycle checkpoint or apoptosis in mESCs. Instead, it stimulates autophagy in a transcriptional-dependent manner involving up-regulation of dram1 gene expression. This study demonstrates a novel mechanism of resveratrol-dependent p53 activation in mESCs.

KW - Animals

KW - Autophagy/drug effects

KW - Cell Cycle Checkpoints/drug effects

KW - Cells, Cultured

KW - Membrane Proteins/genetics

KW - Mice

KW - Mouse Embryonic Stem Cells/cytology

KW - Resveratrol/pharmacology

KW - Tumor Suppressor Protein p53/agonists

KW - Up-Regulation/drug effects

U2 - 10.1016/j.bbrc.2018.08.010

DO - 10.1016/j.bbrc.2018.08.010

M3 - Article

C2 - 30098786

VL - 503

SP - 2180

EP - 2185

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -

ID: 85161344