This article represents primary aspects of Saint Petersburg School of Clinical Psychology and briefly describes its history, as well as the main research goals pursued at the Department of Medical Psychology and Psychophysiology at Saint Petersburg State University, Russia. The main key areas of research presented in the article are the following: studies in the field of theory and methodology of clinical psychology, psychological research in clinical and preventive medicine, research in the field of pediatric and perinatal clinical psychology, research on the theory and practice of psychotherapy, research in psychophysiology, and development of methods for clinical psychodiagnostics.