Regulatory Effects of 5-Day Oral and Intraperitoneal Administration of a Thienopyrimidine Derivative on the Thyroid Status in Rats

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Regulatory Effects of 5-Day Oral and Intraperitoneal Administration of a Thienopyrimidine Derivative on the Thyroid Status in Rats. / Derkach, K V; Sorokoumov, V N; Morina, I Yu; Kuznetsova, V S; Romanova, I V; Shpakov, A O.

In: Bulletin of Experimental Biology and Medicine, Vol. 177, No. 4, 01.08.2024, p. 559-563.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{6a43ac0a2dcf46ed9ed630477669e154,

title = "Regulatory Effects of 5-Day Oral and Intraperitoneal Administration of a Thienopyrimidine Derivative on the Thyroid Status in Rats",

abstract = "In experiments on rats, we studied the effect of 5-day intraperitoneal (15 mg/kg/day) and oral (40 mg/kg/day) administration of compound TPY3m, a stimulator of the production of thyroid hormones by the thyroid gland developed by us, on the blood levels of thyroxine, triiodothyronine, and thyroid-stimulating hormone and on morphology of the thyroid gland. With both routes of administration, TPY3m caused a sustained moderate elevation of thyroid hormones, mainly thyroxine, with little effect on the level of thyroid-stimulating hormone. TPY3m did not reduce the stimulating effect of thyroliberin on the levels of thyroid hormones and had no damaging effect on the thyroid gland. During long-term administration, compound TPY3m stimulates the production of thyroid hormones without weakening the activity of the thyroid axis. Thus, TPY3m is a prototype of drugs for correcting thyroid hormone deficiency.",

keywords = "Animals, Thyroid Gland/drug effects, Rats, Injections, Intraperitoneal, Administration, Oral, Male, Triiodothyronine/blood, Pyrimidines/pharmacology, Thyrotropin/blood, Thyroxine/blood, Rats, Wistar, Thyroid Hormones/blood, thyroxine, hypothyroidism, thyroid gland, allosteric agonist, thyroid-stimulating hormone receptor",

author = "Derkach, {K V} and Sorokoumov, {V N} and Morina, {I Yu} and Kuznetsova, {V S} and Romanova, {I V} and Shpakov, {A O}",

note = "{\textcopyright} 2024. Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2024",

month = aug,

day = "1",

doi = "10.1007/s10517-024-06223-8",

language = "English",

volume = "177",

pages = "559--563",

journal = "Bulletin of Experimental Biology and Medicine",

issn = "0007-4888",

publisher = "Springer Nature",

number = "4",

}

RIS

TY - JOUR

T1 - Regulatory Effects of 5-Day Oral and Intraperitoneal Administration of a Thienopyrimidine Derivative on the Thyroid Status in Rats

AU - Derkach, K V

AU - Sorokoumov, V N

AU - Morina, I Yu

AU - Kuznetsova, V S

AU - Romanova, I V

AU - Shpakov, A O

PY - 2024/8/1

Y1 - 2024/8/1

N2 - In experiments on rats, we studied the effect of 5-day intraperitoneal (15 mg/kg/day) and oral (40 mg/kg/day) administration of compound TPY3m, a stimulator of the production of thyroid hormones by the thyroid gland developed by us, on the blood levels of thyroxine, triiodothyronine, and thyroid-stimulating hormone and on morphology of the thyroid gland. With both routes of administration, TPY3m caused a sustained moderate elevation of thyroid hormones, mainly thyroxine, with little effect on the level of thyroid-stimulating hormone. TPY3m did not reduce the stimulating effect of thyroliberin on the levels of thyroid hormones and had no damaging effect on the thyroid gland. During long-term administration, compound TPY3m stimulates the production of thyroid hormones without weakening the activity of the thyroid axis. Thus, TPY3m is a prototype of drugs for correcting thyroid hormone deficiency.

AB - In experiments on rats, we studied the effect of 5-day intraperitoneal (15 mg/kg/day) and oral (40 mg/kg/day) administration of compound TPY3m, a stimulator of the production of thyroid hormones by the thyroid gland developed by us, on the blood levels of thyroxine, triiodothyronine, and thyroid-stimulating hormone and on morphology of the thyroid gland. With both routes of administration, TPY3m caused a sustained moderate elevation of thyroid hormones, mainly thyroxine, with little effect on the level of thyroid-stimulating hormone. TPY3m did not reduce the stimulating effect of thyroliberin on the levels of thyroid hormones and had no damaging effect on the thyroid gland. During long-term administration, compound TPY3m stimulates the production of thyroid hormones without weakening the activity of the thyroid axis. Thus, TPY3m is a prototype of drugs for correcting thyroid hormone deficiency.

KW - Animals

KW - Thyroid Gland/drug effects

KW - Rats

KW - Injections, Intraperitoneal

KW - Administration, Oral

KW - Male

KW - Triiodothyronine/blood

KW - Pyrimidines/pharmacology

KW - Thyrotropin/blood

KW - Thyroxine/blood

KW - Rats, Wistar

KW - Thyroid Hormones/blood

KW - thyroxine

KW - hypothyroidism

KW - thyroid gland

KW - allosteric agonist

KW - thyroid-stimulating hormone receptor

UR - https://www.mendeley.com/catalogue/1b977816-ac67-34f2-9187-9cef6a07cb2b/

U2 - 10.1007/s10517-024-06223-8

DO - 10.1007/s10517-024-06223-8

M3 - Article

C2 - 39266923

VL - 177

SP - 559

EP - 563

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 4

ER -

ID: 125921134