The article is devoted to problems of formation of cluster systems in NW Russia. Theoretical, methodological and methodical aspects of scientific methods, principles and approaches to formation of cluster systems. Analyzed legislative, regulatory and legal base of formation of clusters, the positive experience of the functioning of cluster systems. The features of clustering, their classification, taking into account geographical, sectoral and industrial specialization of the regions. Identified priorities and identified specific strategic directions of the state cluster policy for the regional and municipal authorities and business entities. Formed system of organizational-methodological and legal documents for governments on the creation of cluster systems in the regions. At the present stage of development of the world economy, the application of new knowledge in production has the character of a continuously accelerating process. Biotechnology, genetic engineering, alternative energy, nanotechnology is currently being actively developed, but is possible on the basis of their development perspective the transition from machine-mechanical technology to "hybrid", where machine technology is used, coupled with information technology opens the door to a new technological revolution. The main factors that determine the quality of innovation policy in the constituent entities of the Russian Federation, and the prospects of creating an open database of regional priorities and the willingness of the regions to systematically embedded within Federal technology initiatives and predictions.