Recombinant tuberculosis allergen (Diaskintest®) in tuberculosis diagnostic in Russia (meta-analysis)

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Recombinant tuberculosis allergen (Diaskintest^®) in tuberculosis diagnostic in Russia (meta-analysis). / Starshinova, Anna; Dovgalyk, Irina; Malkova, Anna; Zinchenko, Yulia; Pavlova, Maria; Belyaeva, Ekaterina; Basantsova, Natalia; Nazarenko, Michail; Kudlay, Dmitry; Yablonskiy, Piotr.

In: International Journal of Mycobacteriology, Vol. 9, No. 4, 01.10.2020, p. 335-346.

Research output: Contribution to journal › Review article › peer-review

Author

Starshinova, Anna ; Dovgalyk, Irina ; Malkova, Anna ; Zinchenko, Yulia ; Pavlova, Maria ; Belyaeva, Ekaterina ; Basantsova, Natalia ; Nazarenko, Michail ; Kudlay, Dmitry ; Yablonskiy, Piotr. / Recombinant tuberculosis allergen (Diaskintest^®) in tuberculosis diagnostic in Russia (meta-analysis). In: International Journal of Mycobacteriology. 2020 ; Vol. 9, No. 4. pp. 335-346.

BibTeX

@article{65a54eb3ebdd4785b5889efe556cb78e,

title = "Recombinant tuberculosis allergen (Diaskintest{\textregistered}) in tuberculosis diagnostic in Russia (meta-analysis)",

abstract = "Immunological testing for tuberculosis has been one of the most rapidly developing areas in the last decade. A new-generation immunological skin test, Diaskintest (DST), has been developed in the Russian Federation and successfully implemented into clinical practice since 2009. This article presents the results of a meta-analysis of publications reporting data on the use of the recombinant tuberculosis allergen DST (n = 121) from 2009 to 2019 included in Russian and international databases. The analysis included a total of 61 papers consistent with the study design, which cumulatively presented the results of 3,777,083 patients tested with DST (83.0%). The obtained data showed that the overall diagnostic sensitivity of the test in this population, regardless of age, was 86.0%, with 98.0% negative results. It was found that the intensity of the immune response of tuberculosis patients to specific ESAT-6 and CFP-10 antigens of DST may depend on the biological properties of the pathogen characteristic to various Mycobacterium tuberculosis genotypes, tuberculosis severity, and the presence of concomitant diseases. These factors are more prevalent in the adult population. In children, however, the test sensitivity reaches 100%. The proportion of positive DST results in HIV-positive patients tested for tuberculosis was 60.0%. The analysis showed that the accuracy (overall validity) of DST was 95.1% in the total studied population (95% confidence interval [CI]: 95.06-95.1) and 92.4% in HIV-positive patients (95% CI: 91.9-92.7).",

keywords = "Diagnostics, Diaskintest, IGRA tests, immunodiagnostics, recombinant tuberculosis allergen, tuberculosis",

author = "Anna Starshinova and Irina Dovgalyk and Anna Malkova and Yulia Zinchenko and Maria Pavlova and Ekaterina Belyaeva and Natalia Basantsova and Michail Nazarenko and Dmitry Kudlay and Piotr Yablonskiy",

year = "2020",

month = oct,

day = "1",

doi = "10.4103/ijmy.ijmy-131-20",

language = "English",

volume = "9",

pages = "335--346",

journal = "International Journal of Mycobacteriology",

issn = "2212-5531",

publisher = "Medknow Publications",

number = "4",

}

RIS

TY - JOUR

T1 - Recombinant tuberculosis allergen (Diaskintest®) in tuberculosis diagnostic in Russia (meta-analysis)

AU - Starshinova, Anna

AU - Dovgalyk, Irina

AU - Malkova, Anna

AU - Zinchenko, Yulia

AU - Pavlova, Maria

AU - Belyaeva, Ekaterina

AU - Basantsova, Natalia

AU - Nazarenko, Michail

AU - Kudlay, Dmitry

AU - Yablonskiy, Piotr

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Immunological testing for tuberculosis has been one of the most rapidly developing areas in the last decade. A new-generation immunological skin test, Diaskintest (DST), has been developed in the Russian Federation and successfully implemented into clinical practice since 2009. This article presents the results of a meta-analysis of publications reporting data on the use of the recombinant tuberculosis allergen DST (n = 121) from 2009 to 2019 included in Russian and international databases. The analysis included a total of 61 papers consistent with the study design, which cumulatively presented the results of 3,777,083 patients tested with DST (83.0%). The obtained data showed that the overall diagnostic sensitivity of the test in this population, regardless of age, was 86.0%, with 98.0% negative results. It was found that the intensity of the immune response of tuberculosis patients to specific ESAT-6 and CFP-10 antigens of DST may depend on the biological properties of the pathogen characteristic to various Mycobacterium tuberculosis genotypes, tuberculosis severity, and the presence of concomitant diseases. These factors are more prevalent in the adult population. In children, however, the test sensitivity reaches 100%. The proportion of positive DST results in HIV-positive patients tested for tuberculosis was 60.0%. The analysis showed that the accuracy (overall validity) of DST was 95.1% in the total studied population (95% confidence interval [CI]: 95.06-95.1) and 92.4% in HIV-positive patients (95% CI: 91.9-92.7).

AB - Immunological testing for tuberculosis has been one of the most rapidly developing areas in the last decade. A new-generation immunological skin test, Diaskintest (DST), has been developed in the Russian Federation and successfully implemented into clinical practice since 2009. This article presents the results of a meta-analysis of publications reporting data on the use of the recombinant tuberculosis allergen DST (n = 121) from 2009 to 2019 included in Russian and international databases. The analysis included a total of 61 papers consistent with the study design, which cumulatively presented the results of 3,777,083 patients tested with DST (83.0%). The obtained data showed that the overall diagnostic sensitivity of the test in this population, regardless of age, was 86.0%, with 98.0% negative results. It was found that the intensity of the immune response of tuberculosis patients to specific ESAT-6 and CFP-10 antigens of DST may depend on the biological properties of the pathogen characteristic to various Mycobacterium tuberculosis genotypes, tuberculosis severity, and the presence of concomitant diseases. These factors are more prevalent in the adult population. In children, however, the test sensitivity reaches 100%. The proportion of positive DST results in HIV-positive patients tested for tuberculosis was 60.0%. The analysis showed that the accuracy (overall validity) of DST was 95.1% in the total studied population (95% confidence interval [CI]: 95.06-95.1) and 92.4% in HIV-positive patients (95% CI: 91.9-92.7).

KW - Diagnostics

KW - Diaskintest

KW - IGRA tests

KW - immunodiagnostics

KW - recombinant tuberculosis allergen

KW - tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=85098186123&partnerID=8YFLogxK

U2 - 10.4103/ijmy.ijmy-131-20

DO - 10.4103/ijmy.ijmy-131-20

M3 - Review article

C2 - 33323648

AN - SCOPUS:85098186123

VL - 9

SP - 335

EP - 346

JO - International Journal of Mycobacteriology

JF - International Journal of Mycobacteriology

SN - 2212-5531

IS - 4

ER -

ID: 77098157