Research output: Contribution to journal › Article › peer-review
Rare cis-configured 2,4-disubstituted 1-alkylpyridines were envisioned as ligands for trace amine associated receptor 1 (TAAR1). They were synthesized in diastereomerically pure form with the decarboxylative Castagnoli–Cushman reac-tion followed by two reduction events. Despite showing no affinity to TAAR1 as was anticipated, these novel, druglike and CNS-focused compounds will be of much utility in sub-sequent lead generation pursuits.
Original language | English |
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Pages (from-to) | 488-489 |
Number of pages | 2 |
Journal | Mendeleev Communications |
Volume | 31 |
Issue number | 4 |
DOIs | |
State | Published - 27 Aug 2021 |
ID: 85025424