Standard

Quantification of prospective type 2 diabetes mellitus biomarkers by stable isotope dilution with bi-labeled standard glycated peptides. / Soboleva, Alena; Modzel, Maciej; Didio, Anna; P ociennik, Halina; Kijewska, Monika; Grischina, Tatiana; Karonova, Tatiana; Bilova, Tatiana; Stefanov, Vasily; Stefanowiczc, Piotr; Frolov, Andrej.

In: Analytical Methods, Vol. 9, 2017, p. 409-418.

Research output: Contribution to journal › Article › peer-review

Harvard

Soboleva, A, Modzel, M, Didio, A, P ociennik, H, Kijewska, M, Grischina, T, Karonova, T, Bilova, T, Stefanov, V, Stefanowiczc, P & Frolov, A 2017, 'Quantification of prospective type 2 diabetes mellitus biomarkers by stable isotope dilution with bi-labeled standard glycated peptides', Analytical Methods, vol. 9, pp. 409-418. https://doi.org/10.1039/c6ay02483a

APA

Soboleva, A., Modzel, M., Didio, A., P ociennik, H., Kijewska, M., Grischina, T., Karonova, T., Bilova, T., Stefanov, V., Stefanowiczc, P., & Frolov, A. (2017). Quantification of prospective type 2 diabetes mellitus biomarkers by stable isotope dilution with bi-labeled standard glycated peptides. Analytical Methods, 9, 409-418. https://doi.org/10.1039/c6ay02483a

Vancouver

Soboleva A, Modzel M, Didio A, P ociennik H, Kijewska M, Grischina T et al. Quantification of prospective type 2 diabetes mellitus biomarkers by stable isotope dilution with bi-labeled standard glycated peptides. Analytical Methods. 2017;9:409-418. https://doi.org/10.1039/c6ay02483a

Author

Soboleva, Alena ; Modzel, Maciej ; Didio, Anna ; P ociennik, Halina ; Kijewska, Monika ; Grischina, Tatiana ; Karonova, Tatiana ; Bilova, Tatiana ; Stefanov, Vasily ; Stefanowiczc, Piotr ; Frolov, Andrej. / Quantification of prospective type 2 diabetes mellitus biomarkers by stable isotope dilution with bi-labeled standard glycated peptides. In: Analytical Methods. 2017 ; Vol. 9. pp. 409-418.

BibTeX

@article{c5a5466dc3ed4b54a4fe0c9834ff4bfe,
title = "Quantification of prospective type 2 diabetes mellitus biomarkers by stable isotope dilution with bi-labeled standard glycated peptides",
abstract = "Type 2 diabetes mellitus (T2DM) is a complex group of disorders, characterized by hyperglycemia, insulin resistance and insulin deficiency. In human blood, hyperglycemia ultimately results in the enhancement of glycation – a posttranslational modification formed by the interaction of protein amino groups with glucose. The resulting fructosamines (Amadori compounds) readily undergo further degradation resulting in advanced glycation end products (AGEs), known to be pro-inflammatory in humans. These compounds are highly heterogeneous and characteristic of advanced stages of the disease, whereas fructosamines are recognized markers of early diabetes stages (HbA1C, glycated albumin). Recently, individual plasma protein glycation sites were proposed as promising T2DM biomarkers sensitive to short-term fluctuations of plasma glucose. However, corresponding absolute quantification strategies, applicable in regular clinical practice, are still not established. Therefore, here we propose a new analytical approach aimi",
keywords = "bi-labeled peptides, glycation, LC-MS, plasma proteins, standard isotope dilution, type 2 diabetes mellitus (T2DM)",
author = "Alena Soboleva and Maciej Modzel and Anna Didio and {P ociennik}, Halina and Monika Kijewska and Tatiana Grischina and Tatiana Karonova and Tatiana Bilova and Vasily Stefanov and Piotr Stefanowiczc and Andrej Frolov",
year = "2017",
doi = "10.1039/c6ay02483a",
language = "English",
volume = "9",
pages = "409--418",
journal = "Analytical Methods",
issn = "1759-9660",
publisher = "Royal Society of Chemistry",

}

RIS

TY - JOUR

T1 - Quantification of prospective type 2 diabetes mellitus biomarkers by stable isotope dilution with bi-labeled standard glycated peptides

AU - Soboleva, Alena

AU - Modzel, Maciej

AU - Didio, Anna

AU - P ociennik, Halina

AU - Kijewska, Monika

AU - Grischina, Tatiana

AU - Karonova, Tatiana

AU - Bilova, Tatiana

AU - Stefanov, Vasily

AU - Stefanowiczc, Piotr

AU - Frolov, Andrej

PY - 2017

Y1 - 2017

N2 - Type 2 diabetes mellitus (T2DM) is a complex group of disorders, characterized by hyperglycemia, insulin resistance and insulin deficiency. In human blood, hyperglycemia ultimately results in the enhancement of glycation – a posttranslational modification formed by the interaction of protein amino groups with glucose. The resulting fructosamines (Amadori compounds) readily undergo further degradation resulting in advanced glycation end products (AGEs), known to be pro-inflammatory in humans. These compounds are highly heterogeneous and characteristic of advanced stages of the disease, whereas fructosamines are recognized markers of early diabetes stages (HbA1C, glycated albumin). Recently, individual plasma protein glycation sites were proposed as promising T2DM biomarkers sensitive to short-term fluctuations of plasma glucose. However, corresponding absolute quantification strategies, applicable in regular clinical practice, are still not established. Therefore, here we propose a new analytical approach aimi

AB - Type 2 diabetes mellitus (T2DM) is a complex group of disorders, characterized by hyperglycemia, insulin resistance and insulin deficiency. In human blood, hyperglycemia ultimately results in the enhancement of glycation – a posttranslational modification formed by the interaction of protein amino groups with glucose. The resulting fructosamines (Amadori compounds) readily undergo further degradation resulting in advanced glycation end products (AGEs), known to be pro-inflammatory in humans. These compounds are highly heterogeneous and characteristic of advanced stages of the disease, whereas fructosamines are recognized markers of early diabetes stages (HbA1C, glycated albumin). Recently, individual plasma protein glycation sites were proposed as promising T2DM biomarkers sensitive to short-term fluctuations of plasma glucose. However, corresponding absolute quantification strategies, applicable in regular clinical practice, are still not established. Therefore, here we propose a new analytical approach aimi

KW - bi-labeled peptides

KW - glycation

KW - LC-MS

KW - plasma proteins

KW - standard isotope dilution

KW - type 2 diabetes mellitus (T2DM)

U2 - 10.1039/c6ay02483a

DO - 10.1039/c6ay02483a

M3 - Article

VL - 9

SP - 409

EP - 418

JO - Analytical Methods

JF - Analytical Methods

SN - 1759-9660

ER -

ID: 7733711