TY - JOUR

T1 - Pulmonary Artery Hypertension in Ankylosing Spondylitis:

T2 - A Review

AU - Карвалью, Жозелио Фрейре

AU - Гаврилова, Наталия Юрьевна

AU - Сопрун, Лидия Александровна

AU - Шишкин, Александр Николаевич

AU - Чурилов, Леонид Павлович

PY - 2025/8/30

Y1 - 2025/8/30

N2 - Pulmonary arterial hypertension (PAH) is a serious complication that can occur in patients with connective tissue diseases, such as ankylosing spondylitis (AS). This review discusses the cases of PAH in patients with AS, and the issues related to the pathogenesis of pulmonary dysfunction in this condition. The pathogenesis of PAH in AS involves several factors, including systemic inflammation, endothelial dysfunction, oxidative stress, and an imbalance of vasodilators and vasoconstrictors. However, the literature on this topic is limited, with only a few studies available on July 2025. Of the published studies, three were case reports and two were observational studies, with a total of 104 patients. PAH was more commonly found in middle-aged men who had a long history of AS. The most common clinical symptoms included shortness of breath during exercise, leg swelling, and palpitations. Risk factors for PAH in these patients include age, duration of AS, smoking history, severe functional impairments, and evidence of endothelial dysfunction. The authors emphasize the importance of early cardiological screening for patients with prolonged and severe AS, and call for studies to assess the effectiveness of specific PAH treatment in this group of patients.

AB - Pulmonary arterial hypertension (PAH) is a serious complication that can occur in patients with connective tissue diseases, such as ankylosing spondylitis (AS). This review discusses the cases of PAH in patients with AS, and the issues related to the pathogenesis of pulmonary dysfunction in this condition. The pathogenesis of PAH in AS involves several factors, including systemic inflammation, endothelial dysfunction, oxidative stress, and an imbalance of vasodilators and vasoconstrictors. However, the literature on this topic is limited, with only a few studies available on July 2025. Of the published studies, three were case reports and two were observational studies, with a total of 104 patients. PAH was more commonly found in middle-aged men who had a long history of AS. The most common clinical symptoms included shortness of breath during exercise, leg swelling, and palpitations. Risk factors for PAH in these patients include age, duration of AS, smoking history, severe functional impairments, and evidence of endothelial dysfunction. The authors emphasize the importance of early cardiological screening for patients with prolonged and severe AS, and call for studies to assess the effectiveness of specific PAH treatment in this group of patients.

KW - Rheumatic diseases

KW - Pulmonary arterial hypertension

KW - Ankylosing spondylitis

U2 - 10.32415/jscientia_2025_11_4_5-12

DO - 10.32415/jscientia_2025_11_4_5-12

M3 - Article

VL - 11

SP - 5

EP - 12

JO - JUVENIS SCIENTIA

JF - JUVENIS SCIENTIA

SN - 2414-3782

IS - 4

ER -