Aim. To study quality of life of patients with progressive renal pathology at the stage of conservative treatment. Material and methods. Quality of life and psychological features were examined in 40 patients with renal diseases (40% males, mean age 48.6 ± 1.3 years). 77.5% examinees suffered from glomerulonephritis, the rest had diabetic nephropathy. Results. Personality, behavioral features of the patients were characterized as well as relationships between psychological and somatic factors in development of the disease. Factors influencing quality of life of the above patients are described. Conclusion. Correction of the variables influencing, primarily, the psychological component of the quality of life and, by this component, satisfaction of the patients with their state as a whole may have a good effect on their rehabilitation.