Research output: Contribution to journal › Article › peer-review
Protecting the skin-implant interface with transcutaneous silver-coated skin-and-bone-integrated pylon in pig and rabbit dorsum models. / Shevtsov, Maxim; Gavrilov, Dmitriy; Yudintceva, Natalia; Zemtsova, Elena; Arbenin, Andrei; Smirnov, Vladimir; Voronkina, Irina; Adamova, Polina; Blinova, Miralda; Mikhailova, Nataliya; Galibin, Oleg; Akkaoui, Michael; Pitkin, Mark.
In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 109, No. 4, 16.09.2020, p. 584-595.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Protecting the skin-implant interface with transcutaneous silver-coated skin-and-bone-integrated pylon in pig and rabbit dorsum models
AU - Shevtsov, Maxim
AU - Gavrilov, Dmitriy
AU - Yudintceva, Natalia
AU - Zemtsova, Elena
AU - Arbenin, Andrei
AU - Smirnov, Vladimir
AU - Voronkina, Irina
AU - Adamova, Polina
AU - Blinova, Miralda
AU - Mikhailova, Nataliya
AU - Galibin, Oleg
AU - Akkaoui, Michael
AU - Pitkin, Mark
N1 - Publisher Copyright: © 2020 Wiley Periodicals LLC Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9/16
Y1 - 2020/9/16
N2 - Implant-associated soft tissue infections at the skin-implant interface represent the most frequent complications in reconstructive surgery and lead to implant failures and revisions. Titanium implants with deep porosity, called skin-and-bone-integrated-pylons (SBIP), allow for skin ingrowth in the morphologically natural direction, thus restoring a reliable dermal barrier and reducing the risk of infection. Silver coating of the SBIP implant surface using physical vapor deposition technique offers the possibility of preventing biofilm formation and exerting a direct antimicrobial effect during the wound healing phase. In vivo studies employing pig and rabbit dorsum models for assessment of skin ingrowth into the pores of the pylon demonstrated the safety of transcutaneous implantation of the SBIP system. No postoperative complications were reported at the end of the follow-up period of 6 months. Histological analysis proved skin ingrowth in the minipig model without signs of silver toxicity. Analysis of silver release (using energy dispersive X-ray spectroscopy) in the model of intramedullary-inserted silver-coated SBIP in New Zealand rabbits demonstrated trace amounts of silver after 3 months of in-bone implantation. In conclusion, selected temporary silver coating of the SBIP implant surface is powerful at preventing the periprosthetic infections without imparing skin ingrowth and can be considered for clinical application.
AB - Implant-associated soft tissue infections at the skin-implant interface represent the most frequent complications in reconstructive surgery and lead to implant failures and revisions. Titanium implants with deep porosity, called skin-and-bone-integrated-pylons (SBIP), allow for skin ingrowth in the morphologically natural direction, thus restoring a reliable dermal barrier and reducing the risk of infection. Silver coating of the SBIP implant surface using physical vapor deposition technique offers the possibility of preventing biofilm formation and exerting a direct antimicrobial effect during the wound healing phase. In vivo studies employing pig and rabbit dorsum models for assessment of skin ingrowth into the pores of the pylon demonstrated the safety of transcutaneous implantation of the SBIP system. No postoperative complications were reported at the end of the follow-up period of 6 months. Histological analysis proved skin ingrowth in the minipig model without signs of silver toxicity. Analysis of silver release (using energy dispersive X-ray spectroscopy) in the model of intramedullary-inserted silver-coated SBIP in New Zealand rabbits demonstrated trace amounts of silver after 3 months of in-bone implantation. In conclusion, selected temporary silver coating of the SBIP implant surface is powerful at preventing the periprosthetic infections without imparing skin ingrowth and can be considered for clinical application.
KW - implants
KW - osseointegration
KW - silver coating
KW - skin-and-bone-integrated-pylon
KW - skin-implant interface
KW - EFFICACY
KW - WOUNDS
KW - SOCKET
KW - POROUS TITANIUM
KW - OSSEOINTEGRATION
KW - PROSTHETIC PYLON
KW - TRANSFEMORAL AMPUTATION
UR - http://www.scopus.com/inward/record.url?scp=85090950944&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/c1a45e7f-0f63-32b3-9c8a-2b476aa92194/
U2 - 10.1002/jbm.b.34725
DO - 10.1002/jbm.b.34725
M3 - Article
AN - SCOPUS:85090950944
VL - 109
SP - 584
EP - 595
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
SN - 1552-4973
IS - 4
ER -
ID: 69891200