Research output: Contribution to journal › Article › peer-review
Prognostic value of stress echocardiography assessed by the ABCDE protocol. / Ciampi, Quirino; Zagatina, Angela; Cortigiani, Lauro; Wierzbowska-Drabik, Karina; Kasprzak, Jaroslaw D.; Haberka, MacIej; Djordjevic-DIkic, Ana; Beleslin, Branko; Boshchenko, Alla; Ryabova, Tamara; Gaibazzi, Nicola; Rigo, Fausto; Dodi, Claudio; Simova, Iana; Samardjieva, Martina; Barbieri, Andrea; Morrone, Doralisa; Lorenzoni, Valentina; Prota, Costantina; Villari, Bruno; Antonini-Canterin, Francesco; Pepi, Mauro; Carpeggiani, Clara; Pellikka, Patricia A.; Picano, Eugenio.
In: European Heart Journal, Vol. 42, No. 37, 01.10.2021, p. 3869-3878.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Prognostic value of stress echocardiography assessed by the ABCDE protocol
AU - Ciampi, Quirino
AU - Zagatina, Angela
AU - Cortigiani, Lauro
AU - Wierzbowska-Drabik, Karina
AU - Kasprzak, Jaroslaw D.
AU - Haberka, MacIej
AU - Djordjevic-DIkic, Ana
AU - Beleslin, Branko
AU - Boshchenko, Alla
AU - Ryabova, Tamara
AU - Gaibazzi, Nicola
AU - Rigo, Fausto
AU - Dodi, Claudio
AU - Simova, Iana
AU - Samardjieva, Martina
AU - Barbieri, Andrea
AU - Morrone, Doralisa
AU - Lorenzoni, Valentina
AU - Prota, Costantina
AU - Villari, Bruno
AU - Antonini-Canterin, Francesco
AU - Pepi, Mauro
AU - Carpeggiani, Clara
AU - Pellikka, Patricia A.
AU - Picano, Eugenio
N1 - Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Aim: The aim of this study was to assess the prognostic value of ABCDE-SE in a prospective, large scale, multicentre, international, effectiveness study. Stress echocardiography (SE) was recently upgraded to the ABCDE protocol: step A, regional wall motion abnormalities; step B, B lines; step C, left ventricular contractile reserve; step D, Doppler-based coronary flow velocity reserve in left anterior descending coronary artery; and step E, electrocardiogram-based heart rate reserve. Methods and results: From July 2016 to November 2020, we enrolled 3574 all-comers (age 65 ± 11 years, 2070 males, 58%; ejection fraction 60 ± 10%) with known or suspected chronic coronary syndromes referred from 13 certified laboratories. All patients underwent clinically indicated ABCDE-SE. The employed stress modality was exercise (n = 952, with semi-supine bike, n = 887, or treadmill, n = 65 with adenosine for step D) or pharmacological stress (n = 2622, with vasodilator, n = 2151; or dobutamine, n = 471). SE response ranged from score 0 (all steps normal) to score 5 (all steps abnormal). All-cause death was the only endpoint. Rate of abnormal results was 16% for A, 30% for B, 36% for C, 28% for D, and 37% for E steps. During a median follow-up of 21 months (interquartile range: 13-36), 73 deaths occurred. Global X2 was 49.5 considering clinical variables, 50.7 after step A only (P = NS (not significant)) and 80.6 after B-E steps (P < 0.001 vs. step A). Annual mortality rate ranged from 0.4% person-year for score 0 up to 2.7% person-year for score 5. Conclusion: ABCDE-SE allows an effective prediction of survival in patients with chronic coronary syndromes.
AB - Aim: The aim of this study was to assess the prognostic value of ABCDE-SE in a prospective, large scale, multicentre, international, effectiveness study. Stress echocardiography (SE) was recently upgraded to the ABCDE protocol: step A, regional wall motion abnormalities; step B, B lines; step C, left ventricular contractile reserve; step D, Doppler-based coronary flow velocity reserve in left anterior descending coronary artery; and step E, electrocardiogram-based heart rate reserve. Methods and results: From July 2016 to November 2020, we enrolled 3574 all-comers (age 65 ± 11 years, 2070 males, 58%; ejection fraction 60 ± 10%) with known or suspected chronic coronary syndromes referred from 13 certified laboratories. All patients underwent clinically indicated ABCDE-SE. The employed stress modality was exercise (n = 952, with semi-supine bike, n = 887, or treadmill, n = 65 with adenosine for step D) or pharmacological stress (n = 2622, with vasodilator, n = 2151; or dobutamine, n = 471). SE response ranged from score 0 (all steps normal) to score 5 (all steps abnormal). All-cause death was the only endpoint. Rate of abnormal results was 16% for A, 30% for B, 36% for C, 28% for D, and 37% for E steps. During a median follow-up of 21 months (interquartile range: 13-36), 73 deaths occurred. Global X2 was 49.5 considering clinical variables, 50.7 after step A only (P = NS (not significant)) and 80.6 after B-E steps (P < 0.001 vs. step A). Annual mortality rate ranged from 0.4% person-year for score 0 up to 2.7% person-year for score 5. Conclusion: ABCDE-SE allows an effective prediction of survival in patients with chronic coronary syndromes.
KW - Echocardiography
KW - Outcome
KW - Stress
KW - Vulnerability
KW - Prognosis
KW - Prospective Studies
KW - Humans
KW - Middle Aged
KW - Dobutamine
KW - Male
KW - Echocardiography, Stress
KW - Aged
KW - Coronary Vessels/diagnostic imaging
KW - CORONARY FLOW VELOCITY
KW - EUROPEAN ASSOCIATION
KW - HEART-DISEASE
KW - RESERVE
KW - RECOMMENDATIONS
KW - ARTERY
KW - AMERICAN SOCIETY
UR - http://www.scopus.com/inward/record.url?scp=85113764380&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/7e37c2cc-5df1-39cf-9d73-3cfa11e25898/
U2 - 10.1093/eurheartj/ehab493
DO - 10.1093/eurheartj/ehab493
M3 - Article
C2 - 34449837
AN - SCOPUS:85113764380
VL - 42
SP - 3869
EP - 3878
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 37
ER -
ID: 87656726