Research output: Contribution to journal › Article › peer-review
Progesterone and anxiety during the oestrus cycle in rats genetically selected for high and low active avoidance. / Жуков, Дмитрий Анатольевич; Арутюнян, Наталия Алексеевна; Виноградова, Екатерина Павловна.
In: Integrative Physiology, Vol. 1, No. 2, 2020, p. 151-155.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Progesterone and anxiety during the oestrus cycle in rats genetically selected for high and low active avoidance
AU - Жуков, Дмитрий Анатольевич
AU - Арутюнян, Наталия Алексеевна
AU - Виноградова, Екатерина Павловна
PY - 2020
Y1 - 2020
N2 - In this research, the changes of anxiety and blood progesterone levels during the oestrus cycle were studied in rats genetically selected for high (KHA) and low (KLA) acquisition of active avoidance. Anxiety levels were measured by the time spent in open arms of the elevated plus-maze. Progesterone levels were determined by radioimmunoassay. KLA rats exhibited no significant changes in anxiety levels during the oestrus cycle. KHA rats showed a significant variation of anxiety during the oestrus cycle with a high level in the diestrus phase and a low level in proestrus. Moreover, anxiety in diestrus in KHA rats was higher than in KLA rats. Additionally, increased progesterone levels were observed in KLA rats in comparison with the KHA strain, during both diestrus and proestrus. Anxiety levels corresponded to plasma progesterone during the oestrus cycle in both rat strains.
AB - In this research, the changes of anxiety and blood progesterone levels during the oestrus cycle were studied in rats genetically selected for high (KHA) and low (KLA) acquisition of active avoidance. Anxiety levels were measured by the time spent in open arms of the elevated plus-maze. Progesterone levels were determined by radioimmunoassay. KLA rats exhibited no significant changes in anxiety levels during the oestrus cycle. KHA rats showed a significant variation of anxiety during the oestrus cycle with a high level in the diestrus phase and a low level in proestrus. Moreover, anxiety in diestrus in KHA rats was higher than in KLA rats. Additionally, increased progesterone levels were observed in KLA rats in comparison with the KHA strain, during both diestrus and proestrus. Anxiety levels corresponded to plasma progesterone during the oestrus cycle in both rat strains.
KW - progesterone
KW - anxiety
KW - oestrus cycle
KW - active avoidance
KW - Coping style
UR - https://intphysiology.ru/index.php/main/article/view/4
U2 - 10.33910/2687-1270-2020-1-2-151-155
DO - 10.33910/2687-1270-2020-1-2-151-155
M3 - Article
VL - 1
SP - 151
EP - 155
JO - Интегративная физиология
JF - Интегративная физиология
SN - 2687-1270
IS - 2
ER -
ID: 73176450