Standard

Prevalence and antibiotic resistance of carbapenemase-producing Gram-negative bacteria in Saint Petersburg and some other regions of the Russian Federation. / Lazareva, I. V.; Ageevets, V. A.; Ershova, T. A.; Zueva, L. P.; Goncharov, A. E.; Darina, M. G.; Svetlichnaya, Yu S.; Uskov, A. N.; Sidorenko, S. V.

In: Antibiotiki i Khimioterapiya, Vol. 61, No. 11-12, 01.01.2016, p. 28-38.

Research output: Contribution to journalArticlepeer-review

Harvard

Lazareva, IV, Ageevets, VA, Ershova, TA, Zueva, LP, Goncharov, AE, Darina, MG, Svetlichnaya, YS, Uskov, AN & Sidorenko, SV 2016, 'Prevalence and antibiotic resistance of carbapenemase-producing Gram-negative bacteria in Saint Petersburg and some other regions of the Russian Federation', Antibiotiki i Khimioterapiya, vol. 61, no. 11-12, pp. 28-38.

APA

Lazareva, I. V., Ageevets, V. A., Ershova, T. A., Zueva, L. P., Goncharov, A. E., Darina, M. G., Svetlichnaya, Y. S., Uskov, A. N., & Sidorenko, S. V. (2016). Prevalence and antibiotic resistance of carbapenemase-producing Gram-negative bacteria in Saint Petersburg and some other regions of the Russian Federation. Antibiotiki i Khimioterapiya, 61(11-12), 28-38.

Vancouver

Lazareva IV, Ageevets VA, Ershova TA, Zueva LP, Goncharov AE, Darina MG et al. Prevalence and antibiotic resistance of carbapenemase-producing Gram-negative bacteria in Saint Petersburg and some other regions of the Russian Federation. Antibiotiki i Khimioterapiya. 2016 Jan 1;61(11-12):28-38.

Author

Lazareva, I. V. ; Ageevets, V. A. ; Ershova, T. A. ; Zueva, L. P. ; Goncharov, A. E. ; Darina, M. G. ; Svetlichnaya, Yu S. ; Uskov, A. N. ; Sidorenko, S. V. / Prevalence and antibiotic resistance of carbapenemase-producing Gram-negative bacteria in Saint Petersburg and some other regions of the Russian Federation. In: Antibiotiki i Khimioterapiya. 2016 ; Vol. 61, No. 11-12. pp. 28-38.

BibTeX

@article{db67d32b0d99492ba1005c53035616a6,
title = "Prevalence and antibiotic resistance of carbapenemase-producing Gram-negative bacteria in Saint Petersburg and some other regions of the Russian Federation",
abstract = "Carbapenemase producers were also detected in hospitals of Moscow, Yekaterinburg, Vologda, Murmansk, Kurgan, Krasnoyarsk, Izhevsk, Krasnodar and Perm. In total 281 carbapenemase producers were recorded within 2011-2016, which were isolated from infected or colonized patients (K.pneumoniae - 247 isolates, Acinetobacter spp - 29 isolates, Enterobacter cloacae - 2 isolates, Serratia marcescens - 1 isolate, Escherichia coll - 1 isolate and Proteus mirabilis - 1 isolate). The carbapenemase-producing K.pneumoniae isolates were distinguished by considerable genetic diversity, the NDM-type carbapenemase-producers belonged to eight, KPC-type - to three and OXA-48-type - to four different sequence-types (STs) respectively. The representatives of the globally dominant genetic line, Clonal Group 258(CG258), and also a number of the less common lines (ST147, ST273, ST307 and ST377) were detected. The K.pneumoniae strains were distinguished by a high frequency of cross-resistance and the associated resistance to antibiotics of different groups. The frequency of resistance to cephalosporins and fluoroquinolones reached 100%. Among the NDM-type carbapenemase producers the frequency of resistance to aminoglycosides exceeded 90%, among the KPC-type carbapenemase producers the frequency of resistance corresponded to 66% for amikacin and 93% for gentamicin, among the OXA-48 type carbapenemase producers the frequency of resistance was even lower (50% and 73% respectively). Approximately 80% of the NDM-type, 90% of the KPC-type and only 60% of the OXA-48-type carbapenemase producers showed a high level of resistance to imipenem and meropenem. The frequency of resistance to tigecycline varied within 6.7% to 14.8% and the frequency of resistance to polymyxin was within 4.2% to 20%. The OXA-40- and OXA-23-types carbapenemase-producing Acinetobacter spp. remained susceptible only to polymyxin. It is obvious that the possibility of antibacterial therapy of infections caused by carbapenemases producers is limited.",
keywords = "Carbapenemase, Gram-negative bacteria, Resistance",
author = "Lazareva, {I. V.} and Ageevets, {V. A.} and Ershova, {T. A.} and Zueva, {L. P.} and Goncharov, {A. E.} and Darina, {M. G.} and Svetlichnaya, {Yu S.} and Uskov, {A. N.} and Sidorenko, {S. V.}",
year = "2016",
month = jan,
day = "1",
language = "русский",
volume = "61",
pages = "28--38",
journal = "АНТИБИОТИКИ И ХИМИОТЕРАПИЯ",
issn = "0235-2990",
publisher = "Медиа Сфера",
number = "11-12",

}

RIS

TY - JOUR

T1 - Prevalence and antibiotic resistance of carbapenemase-producing Gram-negative bacteria in Saint Petersburg and some other regions of the Russian Federation

AU - Lazareva, I. V.

AU - Ageevets, V. A.

AU - Ershova, T. A.

AU - Zueva, L. P.

AU - Goncharov, A. E.

AU - Darina, M. G.

AU - Svetlichnaya, Yu S.

AU - Uskov, A. N.

AU - Sidorenko, S. V.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Carbapenemase producers were also detected in hospitals of Moscow, Yekaterinburg, Vologda, Murmansk, Kurgan, Krasnoyarsk, Izhevsk, Krasnodar and Perm. In total 281 carbapenemase producers were recorded within 2011-2016, which were isolated from infected or colonized patients (K.pneumoniae - 247 isolates, Acinetobacter spp - 29 isolates, Enterobacter cloacae - 2 isolates, Serratia marcescens - 1 isolate, Escherichia coll - 1 isolate and Proteus mirabilis - 1 isolate). The carbapenemase-producing K.pneumoniae isolates were distinguished by considerable genetic diversity, the NDM-type carbapenemase-producers belonged to eight, KPC-type - to three and OXA-48-type - to four different sequence-types (STs) respectively. The representatives of the globally dominant genetic line, Clonal Group 258(CG258), and also a number of the less common lines (ST147, ST273, ST307 and ST377) were detected. The K.pneumoniae strains were distinguished by a high frequency of cross-resistance and the associated resistance to antibiotics of different groups. The frequency of resistance to cephalosporins and fluoroquinolones reached 100%. Among the NDM-type carbapenemase producers the frequency of resistance to aminoglycosides exceeded 90%, among the KPC-type carbapenemase producers the frequency of resistance corresponded to 66% for amikacin and 93% for gentamicin, among the OXA-48 type carbapenemase producers the frequency of resistance was even lower (50% and 73% respectively). Approximately 80% of the NDM-type, 90% of the KPC-type and only 60% of the OXA-48-type carbapenemase producers showed a high level of resistance to imipenem and meropenem. The frequency of resistance to tigecycline varied within 6.7% to 14.8% and the frequency of resistance to polymyxin was within 4.2% to 20%. The OXA-40- and OXA-23-types carbapenemase-producing Acinetobacter spp. remained susceptible only to polymyxin. It is obvious that the possibility of antibacterial therapy of infections caused by carbapenemases producers is limited.

AB - Carbapenemase producers were also detected in hospitals of Moscow, Yekaterinburg, Vologda, Murmansk, Kurgan, Krasnoyarsk, Izhevsk, Krasnodar and Perm. In total 281 carbapenemase producers were recorded within 2011-2016, which were isolated from infected or colonized patients (K.pneumoniae - 247 isolates, Acinetobacter spp - 29 isolates, Enterobacter cloacae - 2 isolates, Serratia marcescens - 1 isolate, Escherichia coll - 1 isolate and Proteus mirabilis - 1 isolate). The carbapenemase-producing K.pneumoniae isolates were distinguished by considerable genetic diversity, the NDM-type carbapenemase-producers belonged to eight, KPC-type - to three and OXA-48-type - to four different sequence-types (STs) respectively. The representatives of the globally dominant genetic line, Clonal Group 258(CG258), and also a number of the less common lines (ST147, ST273, ST307 and ST377) were detected. The K.pneumoniae strains were distinguished by a high frequency of cross-resistance and the associated resistance to antibiotics of different groups. The frequency of resistance to cephalosporins and fluoroquinolones reached 100%. Among the NDM-type carbapenemase producers the frequency of resistance to aminoglycosides exceeded 90%, among the KPC-type carbapenemase producers the frequency of resistance corresponded to 66% for amikacin and 93% for gentamicin, among the OXA-48 type carbapenemase producers the frequency of resistance was even lower (50% and 73% respectively). Approximately 80% of the NDM-type, 90% of the KPC-type and only 60% of the OXA-48-type carbapenemase producers showed a high level of resistance to imipenem and meropenem. The frequency of resistance to tigecycline varied within 6.7% to 14.8% and the frequency of resistance to polymyxin was within 4.2% to 20%. The OXA-40- and OXA-23-types carbapenemase-producing Acinetobacter spp. remained susceptible only to polymyxin. It is obvious that the possibility of antibacterial therapy of infections caused by carbapenemases producers is limited.

KW - Carbapenemase

KW - Gram-negative bacteria

KW - Resistance

UR - http://www.scopus.com/inward/record.url?scp=85035111265&partnerID=8YFLogxK

M3 - статья

C2 - 29558058

AN - SCOPUS:85035111265

VL - 61

SP - 28

EP - 38

JO - АНТИБИОТИКИ И ХИМИОТЕРАПИЯ

JF - АНТИБИОТИКИ И ХИМИОТЕРАПИЯ

SN - 0235-2990

IS - 11-12

ER -

ID: 45181990