Prevalence and antibiotic resistance of carbapenemase-producing Gram-negative bacteria in Saint Petersburg and some other regions of the Russian Federation. / Lazareva, I. V.; Ageevets, V. A.; Ershova, T. A.; Zueva, L. P.; Goncharov, A. E.; Darina, M. G.; Svetlichnaya, Yu S.; Uskov, A. N.; Sidorenko, S. V.
In: Antibiotiki i Khimioterapiya, Vol. 61, No. 11-12, 01.01.2016, p. 28-38.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Prevalence and antibiotic resistance of carbapenemase-producing Gram-negative bacteria in Saint Petersburg and some other regions of the Russian Federation
AU - Lazareva, I. V.
AU - Ageevets, V. A.
AU - Ershova, T. A.
AU - Zueva, L. P.
AU - Goncharov, A. E.
AU - Darina, M. G.
AU - Svetlichnaya, Yu S.
AU - Uskov, A. N.
AU - Sidorenko, S. V.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Carbapenemase producers were also detected in hospitals of Moscow, Yekaterinburg, Vologda, Murmansk, Kurgan, Krasnoyarsk, Izhevsk, Krasnodar and Perm. In total 281 carbapenemase producers were recorded within 2011-2016, which were isolated from infected or colonized patients (K.pneumoniae - 247 isolates, Acinetobacter spp - 29 isolates, Enterobacter cloacae - 2 isolates, Serratia marcescens - 1 isolate, Escherichia coll - 1 isolate and Proteus mirabilis - 1 isolate). The carbapenemase-producing K.pneumoniae isolates were distinguished by considerable genetic diversity, the NDM-type carbapenemase-producers belonged to eight, KPC-type - to three and OXA-48-type - to four different sequence-types (STs) respectively. The representatives of the globally dominant genetic line, Clonal Group 258(CG258), and also a number of the less common lines (ST147, ST273, ST307 and ST377) were detected. The K.pneumoniae strains were distinguished by a high frequency of cross-resistance and the associated resistance to antibiotics of different groups. The frequency of resistance to cephalosporins and fluoroquinolones reached 100%. Among the NDM-type carbapenemase producers the frequency of resistance to aminoglycosides exceeded 90%, among the KPC-type carbapenemase producers the frequency of resistance corresponded to 66% for amikacin and 93% for gentamicin, among the OXA-48 type carbapenemase producers the frequency of resistance was even lower (50% and 73% respectively). Approximately 80% of the NDM-type, 90% of the KPC-type and only 60% of the OXA-48-type carbapenemase producers showed a high level of resistance to imipenem and meropenem. The frequency of resistance to tigecycline varied within 6.7% to 14.8% and the frequency of resistance to polymyxin was within 4.2% to 20%. The OXA-40- and OXA-23-types carbapenemase-producing Acinetobacter spp. remained susceptible only to polymyxin. It is obvious that the possibility of antibacterial therapy of infections caused by carbapenemases producers is limited.
AB - Carbapenemase producers were also detected in hospitals of Moscow, Yekaterinburg, Vologda, Murmansk, Kurgan, Krasnoyarsk, Izhevsk, Krasnodar and Perm. In total 281 carbapenemase producers were recorded within 2011-2016, which were isolated from infected or colonized patients (K.pneumoniae - 247 isolates, Acinetobacter spp - 29 isolates, Enterobacter cloacae - 2 isolates, Serratia marcescens - 1 isolate, Escherichia coll - 1 isolate and Proteus mirabilis - 1 isolate). The carbapenemase-producing K.pneumoniae isolates were distinguished by considerable genetic diversity, the NDM-type carbapenemase-producers belonged to eight, KPC-type - to three and OXA-48-type - to four different sequence-types (STs) respectively. The representatives of the globally dominant genetic line, Clonal Group 258(CG258), and also a number of the less common lines (ST147, ST273, ST307 and ST377) were detected. The K.pneumoniae strains were distinguished by a high frequency of cross-resistance and the associated resistance to antibiotics of different groups. The frequency of resistance to cephalosporins and fluoroquinolones reached 100%. Among the NDM-type carbapenemase producers the frequency of resistance to aminoglycosides exceeded 90%, among the KPC-type carbapenemase producers the frequency of resistance corresponded to 66% for amikacin and 93% for gentamicin, among the OXA-48 type carbapenemase producers the frequency of resistance was even lower (50% and 73% respectively). Approximately 80% of the NDM-type, 90% of the KPC-type and only 60% of the OXA-48-type carbapenemase producers showed a high level of resistance to imipenem and meropenem. The frequency of resistance to tigecycline varied within 6.7% to 14.8% and the frequency of resistance to polymyxin was within 4.2% to 20%. The OXA-40- and OXA-23-types carbapenemase-producing Acinetobacter spp. remained susceptible only to polymyxin. It is obvious that the possibility of antibacterial therapy of infections caused by carbapenemases producers is limited.
KW - Carbapenemase
KW - Gram-negative bacteria
KW - Resistance
UR - http://www.scopus.com/inward/record.url?scp=85035111265&partnerID=8YFLogxK
M3 - статья
C2 - 29558058
AN - SCOPUS:85035111265
VL - 61
SP - 28
EP - 38
JO - АНТИБИОТИКИ И ХИМИОТЕРАПИЯ
JF - АНТИБИОТИКИ И ХИМИОТЕРАПИЯ
SN - 0235-2990
IS - 11-12
ER -
ID: 45181990