TY - UNPB

T1 - Prarmaco-EEG-Based Classification of Psychotropic Activity of Novel Chromone-Containing Allylmorpholines in Rats

AU - Sysoev, Yuriy

AU - Shits, Darya

AU - Puchik, Maria

AU - Kurmazov, Nikita

AU - Fedorova, Elizaveta

AU - Titovich, Irina

AU - Okovityi, Sergey

PY - 2024/10/21

Y1 - 2024/10/21

N2 - We performed pharmacoencephalographic (Pharmaco-EEG) evaluation of the effects of chromone-containing derivatives of allylmorpholine (molecule 33a at three dose ranges: 50 mg/kg, 100 mg/kg and 300 mg/kg and molecule 33b at the dose of 30 mg/kg. The experiments were carried out in white outbred rats with chronically implanted electrocorticographic (ECoG) electrodes. The training set, used as a reference to determine the pharmacological effects of each dose of the investigated substances, included matrixes of effects of 9 drugs: NMDA receptor antagonist dizocilpine, the D2/D3-dopamine receptor blocker haloperidol, the Mcholinergic receptor blocker tropicamide, the H1/5HT2A-receptor blocker hydroxizine, the acetylcholinesterase inhibitor galantamine, the alpha-2 adrenergic agonist dexmedetomidine, and a GABA-ergic drugs phenibut and phenazepam. It was obtained that the changes in ECoG signal parameters in rats occurring in response to the administration of both compounds were similar to those induced by hydroxyzine and sulpiride. These results suggest that the chromone-containing derivatives of allylmorpholine have antipsychotic and sedative effects. Further testing in behavioral tests is required to confirm these results.

AB - We performed pharmacoencephalographic (Pharmaco-EEG) evaluation of the effects of chromone-containing derivatives of allylmorpholine (molecule 33a at three dose ranges: 50 mg/kg, 100 mg/kg and 300 mg/kg and molecule 33b at the dose of 30 mg/kg. The experiments were carried out in white outbred rats with chronically implanted electrocorticographic (ECoG) electrodes. The training set, used as a reference to determine the pharmacological effects of each dose of the investigated substances, included matrixes of effects of 9 drugs: NMDA receptor antagonist dizocilpine, the D2/D3-dopamine receptor blocker haloperidol, the Mcholinergic receptor blocker tropicamide, the H1/5HT2A-receptor blocker hydroxizine, the acetylcholinesterase inhibitor galantamine, the alpha-2 adrenergic agonist dexmedetomidine, and a GABA-ergic drugs phenibut and phenazepam. It was obtained that the changes in ECoG signal parameters in rats occurring in response to the administration of both compounds were similar to those induced by hydroxyzine and sulpiride. These results suggest that the chromone-containing derivatives of allylmorpholine have antipsychotic and sedative effects. Further testing in behavioral tests is required to confirm these results.

KW - neuropharmacology

KW - pharmaco-EEG

KW - ECoG

KW - naïve Bayes classifier

KW - allylmorpholines

KW - rats

U2 - 10.2139/ssrn.4994160

DO - 10.2139/ssrn.4994160

M3 - Препринт

BT - Prarmaco-EEG-Based Classification of Psychotropic Activity of Novel Chromone-Containing Allylmorpholines in Rats

ER -