Research output: Contribution to journal › Article › peer-review
Potentiometric multisensor system as a possible simple tool for non-invasive prostate cancer diagnostics through urine analysis. / Solovieva, Svetlana; Karnaukh, Mikhail; Panchuk, Vitaly; Andreev, Evgeny; Kartsova, Liudmila; Bessonova, Elena; Legin, Andrey; Wang, Ping; Wan, Hao; Jahatspanian, Igor; Kirsanov, Dmitry.
In: Sensors and Actuators, B: Chemical, Vol. 289, 15.06.2019, p. 42-47.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Potentiometric multisensor system as a possible simple tool for non-invasive prostate cancer diagnostics through urine analysis
AU - Solovieva, Svetlana
AU - Karnaukh, Mikhail
AU - Panchuk, Vitaly
AU - Andreev, Evgeny
AU - Kartsova, Liudmila
AU - Bessonova, Elena
AU - Legin, Andrey
AU - Wang, Ping
AU - Wan, Hao
AU - Jahatspanian, Igor
AU - Kirsanov, Dmitry
PY - 2019/6/15
Y1 - 2019/6/15
N2 - We report a simple potentiometric multisensor system for distinguishing the urine samples from the patients with diagnosed prostate cancer and from healthy control group. The sensors of the system are sensitive towards variety of cationic and anionic species in urine, as well as to the presence of RedOx pairs. The response of the system represents a complex chemical fingerprint of urine sample that can be related with patient status through multivariate modelling. 89 urine samples were studied (43 from cancer patients confirmed by prostatic puncture biopsy and 46 from healthy control group) and variety of multivariate classification techniques was applied to the potentiometric data. The best results were obtained with logistic regression model yielding 100% sensitivity and 93% specificity in the independent test set of samples.
AB - We report a simple potentiometric multisensor system for distinguishing the urine samples from the patients with diagnosed prostate cancer and from healthy control group. The sensors of the system are sensitive towards variety of cationic and anionic species in urine, as well as to the presence of RedOx pairs. The response of the system represents a complex chemical fingerprint of urine sample that can be related with patient status through multivariate modelling. 89 urine samples were studied (43 from cancer patients confirmed by prostatic puncture biopsy and 46 from healthy control group) and variety of multivariate classification techniques was applied to the potentiometric data. The best results were obtained with logistic regression model yielding 100% sensitivity and 93% specificity in the independent test set of samples.
KW - Classification
KW - Diagnostics
KW - Logistic regression
KW - Potentiometric multisensor system
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=85063186208&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2019.03.072
DO - 10.1016/j.snb.2019.03.072
M3 - Article
AN - SCOPUS:85063186208
VL - 289
SP - 42
EP - 47
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
ER -
ID: 40040831