TY - JOUR

T1 - Postnatal growth of the lumbosacral spinal segments in cat

T2 - Their lengths and positions in relation to vertebrae

AU - Shkorbatova, Polina Y.

AU - Lyakhovetskii, Vsevolod A.

AU - Veshchitskii, Aleksandr A.

AU - Bazhenova, Elena Y.

AU - Pavlova, Natalia V.

AU - Musienko, Pavel E.

AU - Merkulyeva, Natalia S.

N1 - Publisher Copyright: © 2022 American Association for Anatomy.

PY - 2022/5/5

Y1 - 2022/5/5

N2 - Cat is a prominent model for investigating neural networks of the lumbosacral spinal cord that control locomotor and visceral activity. We previously proposed an integral function, establishing the topographical relationship between the spinal cord segments and vertebrae in adult animals. Here, we investigated the dynamic of this topographical relationship through early and middle periods of development in kittens. We calculated the length of each vertebra relative to the total length of the region from 13th thoracic (T) to the 7th lumbar (L) vertebrae (V) as well as the length of each segment relative to the total region from T13 to the three-dimensional sacral (S) segment. As in our previous work, the length and position of VL2 were used to establish relationships between the characteristics of the segments and vertebrae. Cubic regression reliably approximates the lengths of segments relative to VL2 length. As the cat aged, the relative length of VT13 and VL1 decreased while the relative length of VL5 increased. The relative length of the T13 and L3 segments increased while the relative length of the S1-S2 segments decreased. The T13-L2 segments are descended monotonically relative to the VL1-VL2 border. The L3-S1 segments are also descended, though with more complex dynamics. The positions of the S2-S3 segments remained unchanged. To conclude, different spinal segments displayed different developmental dynamics. The revealed relationship between vertebrae and lumbosacral spinal segments may be helpful for clearly defining stimulation regions to invoke particular functions, both in experimental studies on the spinal cord and clinical treatment.

AB - Cat is a prominent model for investigating neural networks of the lumbosacral spinal cord that control locomotor and visceral activity. We previously proposed an integral function, establishing the topographical relationship between the spinal cord segments and vertebrae in adult animals. Here, we investigated the dynamic of this topographical relationship through early and middle periods of development in kittens. We calculated the length of each vertebra relative to the total length of the region from 13th thoracic (T) to the 7th lumbar (L) vertebrae (V) as well as the length of each segment relative to the total region from T13 to the three-dimensional sacral (S) segment. As in our previous work, the length and position of VL2 were used to establish relationships between the characteristics of the segments and vertebrae. Cubic regression reliably approximates the lengths of segments relative to VL2 length. As the cat aged, the relative length of VT13 and VL1 decreased while the relative length of VL5 increased. The relative length of the T13 and L3 segments increased while the relative length of the S1-S2 segments decreased. The T13-L2 segments are descended monotonically relative to the VL1-VL2 border. The L3-S1 segments are also descended, though with more complex dynamics. The positions of the S2-S3 segments remained unchanged. To conclude, different spinal segments displayed different developmental dynamics. The revealed relationship between vertebrae and lumbosacral spinal segments may be helpful for clearly defining stimulation regions to invoke particular functions, both in experimental studies on the spinal cord and clinical treatment.

KW - Ascension

KW - cat

KW - development

KW - spinal cord

KW - vertebrae

KW - Cats

KW - Sacrum

KW - Animals

KW - Spinal Cord

KW - Female

KW - Lumbar Vertebrae

UR - http://www.scopus.com/inward/record.url?scp=85129851230&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/2532bbf8-be4a-3054-9dc8-fbc973920966/

U2 - 10.1002/ar.24945

DO - 10.1002/ar.24945

M3 - Article

C2 - 35466553

AN - SCOPUS:85129851230

VL - 306

SP - 831

EP - 843

JO - The Anatomical Record

JF - The Anatomical Record

SN - 1932-8486

IS - 4

ER -