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Polysaccharides in ocular drug delivery. / Dubashynskaya, Natallia; Poshina, Daria; Raik, Sergei; Urtti, Arto; Skorik, Yury A.

In: Pharmaceutics, Vol. 12, No. 1, 22, 01.2020.

Research output: Contribution to journal › Review article › peer-review

Harvard

Dubashynskaya, N, Poshina, D, Raik, S, Urtti, A & Skorik, YA 2020, 'Polysaccharides in ocular drug delivery', Pharmaceutics, vol. 12, no. 1, 22. https://doi.org/10.3390/pharmaceutics12010022

APA

Dubashynskaya, N., Poshina, D., Raik, S., Urtti, A., & Skorik, Y. A. (2020). Polysaccharides in ocular drug delivery. Pharmaceutics, 12(1), [22]. https://doi.org/10.3390/pharmaceutics12010022

Vancouver

Dubashynskaya N, Poshina D, Raik S, Urtti A, Skorik YA. Polysaccharides in ocular drug delivery. Pharmaceutics. 2020 Jan;12(1). 22. https://doi.org/10.3390/pharmaceutics12010022

Author

Dubashynskaya, Natallia ; Poshina, Daria ; Raik, Sergei ; Urtti, Arto ; Skorik, Yury A. / Polysaccharides in ocular drug delivery. In: Pharmaceutics. 2020 ; Vol. 12, No. 1.

BibTeX

@article{ac8e592cadab4691825f877573881b75,
title = "Polysaccharides in ocular drug delivery",
abstract = "Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.",
keywords = "Eye tissue regeneration, Intravitreal administration, Ocular bioavailability, Ocular drug delivery, Periocular administration, Polysaccharide, Topical administration",
author = "Natallia Dubashynskaya and Daria Poshina and Sergei Raik and Arto Urtti and Skorik, {Yury A.}",
note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = jan,
doi = "10.3390/pharmaceutics12010022",
language = "English",
volume = "12",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "1",

}

RIS

TY - JOUR

T1 - Polysaccharides in ocular drug delivery

AU - Dubashynskaya, Natallia

AU - Poshina, Daria

AU - Raik, Sergei

AU - Urtti, Arto

AU - Skorik, Yury A.

N1 - Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2020/1

Y1 - 2020/1

N2 - Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.

AB - Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.

KW - Eye tissue regeneration

KW - Intravitreal administration

KW - Ocular bioavailability

KW - Ocular drug delivery

KW - Periocular administration

KW - Polysaccharide

KW - Topical administration

UR - http://www.scopus.com/inward/record.url?scp=85077328666&partnerID=8YFLogxK

U2 - 10.3390/pharmaceutics12010022

DO - 10.3390/pharmaceutics12010022

M3 - Review article

AN - SCOPUS:85077328666

VL - 12

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 1

M1 - 22

ER -

ID: 97771127