Polymorphism of Saccharomyces cerevisiae Strains in DNA Metabolism Genes

Standard

Polymorphism of Saccharomyces cerevisiae Strains in DNA Metabolism Genes. / Жук, Анна Сергеевна; Лада, Артем Георгиевич; Павлов, Юрий Иванович.

In: International Journal of Molecular Sciences, Vol. 24, No. 9, 7795, 25.04.2023.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{9fccfab914ce420a9b76f4c1e9db8fd9,

title = "Polymorphism of Saccharomyces cerevisiae Strains in DNA Metabolism Genes",

abstract = "Baker's yeast, S. cerevisiae, is an excellent model organism exploited for molecular genetic studies of the mechanisms of genome stability in eukaryotes. Genetic peculiarities of commonly used yeast strains impact the processes of DNA replication, repair, and recombination (RRR). We compared the genomic DNA sequence variation of the five strains that are intensively used for RRR studies. We used yeast next-generation sequencing data to detect the extent and significance of variation in 183 RRR genes. We present a detailed analysis of the differences that were found even in closely related strains. Polymorphisms of common yeast strains should be considered when interpreting the outcomes of genome stability studies, especially in cases of discrepancies between laboratories describing the same phenomena. ",

keywords = "DNA/metabolism, Genomic Instability, Humans, Polymorphism, Genetic, Saccharomyces cerevisiae Proteins/metabolism, Saccharomyces cerevisiae/genetics, DNA replication, genome sequence, yeast Saccharomyces cerevisiae, DNA recombination, DNA repair, genetic polymorphism",

author = "Жук, {Анна Сергеевна} and Лада, {Артем Георгиевич} and Павлов, {Юрий Иванович}",

year = "2023",

month = apr,

day = "25",

doi = "10.3390/ijms24097795",

language = "English",

volume = "24",

journal = "International Journal of Molecular Sciences",

issn = "1422-0067",

publisher = "MDPI AG",

number = "9",

}

RIS

TY - JOUR

T1 - Polymorphism of Saccharomyces cerevisiae Strains in DNA Metabolism Genes

AU - Жук, Анна Сергеевна

AU - Лада, Артем Георгиевич

AU - Павлов, Юрий Иванович

PY - 2023/4/25

Y1 - 2023/4/25

N2 - Baker's yeast, S. cerevisiae, is an excellent model organism exploited for molecular genetic studies of the mechanisms of genome stability in eukaryotes. Genetic peculiarities of commonly used yeast strains impact the processes of DNA replication, repair, and recombination (RRR). We compared the genomic DNA sequence variation of the five strains that are intensively used for RRR studies. We used yeast next-generation sequencing data to detect the extent and significance of variation in 183 RRR genes. We present a detailed analysis of the differences that were found even in closely related strains. Polymorphisms of common yeast strains should be considered when interpreting the outcomes of genome stability studies, especially in cases of discrepancies between laboratories describing the same phenomena.

AB - Baker's yeast, S. cerevisiae, is an excellent model organism exploited for molecular genetic studies of the mechanisms of genome stability in eukaryotes. Genetic peculiarities of commonly used yeast strains impact the processes of DNA replication, repair, and recombination (RRR). We compared the genomic DNA sequence variation of the five strains that are intensively used for RRR studies. We used yeast next-generation sequencing data to detect the extent and significance of variation in 183 RRR genes. We present a detailed analysis of the differences that were found even in closely related strains. Polymorphisms of common yeast strains should be considered when interpreting the outcomes of genome stability studies, especially in cases of discrepancies between laboratories describing the same phenomena.

KW - DNA/metabolism

KW - Genomic Instability

KW - Humans

KW - Polymorphism, Genetic

KW - Saccharomyces cerevisiae Proteins/metabolism

KW - Saccharomyces cerevisiae/genetics

KW - DNA replication

KW - genome sequence

KW - yeast Saccharomyces cerevisiae

KW - DNA recombination

KW - DNA repair

KW - genetic polymorphism

UR - https://www.mendeley.com/catalogue/cf571941-ade8-3f5a-bf90-44aa255c09f0/

U2 - 10.3390/ijms24097795

DO - 10.3390/ijms24097795

M3 - Article

C2 - 37175502

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 9

M1 - 7795

ER -

ID: 114844049