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Pogloshchenie [14C]GAMK srezami kory golovnogo mozga krys; vliianie Ca2+. / Reǐtarova, T. E.; Rozanov, V. A.; Totskiǐ, V. N.
In: Ukrainskii biokhimicheskii zhurnal, Vol. 59, No. 2, 01.03.1987, p. 87-90.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Pogloshchenie [14C]GAMK srezami kory golovnogo mozga krys; vliianie Ca2+.
AU - Reǐtarova, T. E.
AU - Rozanov, V. A.
AU - Totskiǐ, V. N.
PY - 1987/3/1
Y1 - 1987/3/1
N2 - The [14C]GABA uptake by slices (0.3 mm thick) of Wistar rat brain cortex was studied for its dependence on the GABA concentration in the medium, time of incubation and the presence of Ca2+. This process is characterized by the absence of saturation; the uptake by slices increases sharply when the concentration of exogenous [14C]GABA reaches 200 microM. Bicucullin (10(-4) M), an antagonist of GABA, inhibits the accumulation of GABA in the concentration of 0.2 microM by 60%, that evidences for a considerable contribution of the receptor binding to this process. The [14C]GABA uptake when Ca2+ is absent in the incubation medium and when its concentration is 10(-3) M is practically the same and comparatively low concentrations of Ca2+ (10(-6)-10(-4] decrease the GABA uptake.
AB - The [14C]GABA uptake by slices (0.3 mm thick) of Wistar rat brain cortex was studied for its dependence on the GABA concentration in the medium, time of incubation and the presence of Ca2+. This process is characterized by the absence of saturation; the uptake by slices increases sharply when the concentration of exogenous [14C]GABA reaches 200 microM. Bicucullin (10(-4) M), an antagonist of GABA, inhibits the accumulation of GABA in the concentration of 0.2 microM by 60%, that evidences for a considerable contribution of the receptor binding to this process. The [14C]GABA uptake when Ca2+ is absent in the incubation medium and when its concentration is 10(-3) M is practically the same and comparatively low concentrations of Ca2+ (10(-6)-10(-4] decrease the GABA uptake.
UR - http://www.scopus.com/inward/record.url?scp=0023304747&partnerID=8YFLogxK
M3 - статья
C2 - 3033862
AN - SCOPUS:0023304747
VL - 59
SP - 87
EP - 90
JO - Ukrainian biochemical journal
JF - Ukrainian biochemical journal
SN - 2409-4943
IS - 2
ER -
ID: 42771303