Hypertensive disease is a chronic systemic entity characterized by constant blood pressure level elevation above 130/80 mm Hg induced on genetic background by complex of etiological factors causing disorders of vascular tonus and/ or cardiovascular system regulation. We compared the treatment effect of the fixed combination pill (lisinopril, amlodipine, rosuvastatin) with the isolated pill therapy that contained ACE inhibitor (ramipril, lisinopril, perindopril), diuretic (thiazide or loop), statins, calcium channel blocker from minimum to maximally titrated doses — from 5 + 10 + 10 and 2.5 + 12.5 to 10+20+20 and 5+25 in the treatment of the main diseases — hypertensive disease, ischemic heart disease, dyslipidemias, diabetes mellitus type 2, and in postoperative patients (aortocoronary shunts, angioplasty). Methods. Randomized clinical trial with 104 outpatients both male and female older than 40 years. Patients of control group (with diagnosis of hypertensive disease and cholesterol level above 6,0) were recommended the following medicines: ACE inhibitors, thiazide diuretics once daily in the morning, rosuvastatin 10 mg or atorvastatin 20 mg once daily in the evening. Additionally, in cases of poorly controlled hypertension — calcium channel blockers: nifedipine 20 mg in the evenings, and for those with implanted stents and angioplasty — aspirin 75 mg in the evening. Patients of the main group were offered fixed combination pill (lisinopril, amlodipine, rosuvastatin) 5 + 10 + 10 or 10 + 20 + 20 once daily in the evening and aspirin 75 mg in the evening or glucose lowering medication. Results. There was statistically significant difference of pre- and post-treatment values found of systolic blood pressure registered in both groups (p < 0.001) and diastolic blood pressure for control group (p < 0.001). There was statistically significant difference between control and main groups in total cholesterol level. Cholesterol levels were statistically significantly reduced in patients with fixed combined therapy compared to isolated therapy mode (p <0.01). Fixed combined therapy combination treatment was noticed to be more beneficial both in regards to arterial hypertension and concurrent diseases such as diabetes mellitus type 2, congestive heart diseases, and metabolic syndrome as well as in postoperative patients with aorto-coronary shunts, angioplasty, stent placement, strokes and myocardial infarctions episodes.