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Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct. / Meshcheriakov, Anatolii A.; Iurev, Gleb O.; Luttsev, Michail D.; Podolsky, Nikita E.; Ageev, Sergei V.; Petrov, Andrey V.; Vasina, Lubov V.; Solovtsova, Irina L.; Sharoyko, Vladimir V.; Murin, Igor V.; Semenov, Konstantin N.

In: Colloids and Surfaces B: Biointerfaces, Vol. 196, 111338, 12.2020.

Research output: Contribution to journal › Article › peer-review

Harvard

Meshcheriakov, AA, Iurev, GO, Luttsev, MD, Podolsky, NE, Ageev, SV, Petrov, AV, Vasina, LV, Solovtsova, IL, Sharoyko, VV, Murin, IV & Semenov, KN 2020, 'Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct', Colloids and Surfaces B: Biointerfaces, vol. 196, 111338. https://doi.org/10.1016/j.colsurfb.2020.111338

APA

Meshcheriakov, A. A., Iurev, G. O., Luttsev, M. D., Podolsky, N. E., Ageev, S. V., Petrov, A. V., Vasina, L. V., Solovtsova, I. L., Sharoyko, V. V., Murin, I. V., & Semenov, K. N. (2020). Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct. Colloids and Surfaces B: Biointerfaces, 196, [111338]. https://doi.org/10.1016/j.colsurfb.2020.111338

Vancouver

Meshcheriakov AA, Iurev GO, Luttsev MD, Podolsky NE, Ageev SV, Petrov AV et al. Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct. Colloids and Surfaces B: Biointerfaces. 2020 Dec;196. 111338. https://doi.org/10.1016/j.colsurfb.2020.111338

Author

Meshcheriakov, Anatolii A. ; Iurev, Gleb O. ; Luttsev, Michail D. ; Podolsky, Nikita E. ; Ageev, Sergei V. ; Petrov, Andrey V. ; Vasina, Lubov V. ; Solovtsova, Irina L. ; Sharoyko, Vladimir V. ; Murin, Igor V. ; Semenov, Konstantin N. / Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct. In: Colloids and Surfaces B: Biointerfaces. 2020 ; Vol. 196.

BibTeX

@article{afda94ef7f9c4395816dda6deac112e5,
title = "Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct",
abstract = "Amino acid adducts of light fullerenes have a potential of application in a variety of fields of biomedicine, that is reactive oxygen species scavenging activity, anticancer activity, viruses and bacteria inactivation etc. In this work, the water-soluble C60 fullerene derivative with L-hydroxyproline (C60(C5H9NO3)2, C60-Hyp) was studied. Extensive biomedical investigation of this compound, namely, antiradical activity in the reaction with stable diphenylpicrylhydrazyl radical, the binding to human serum albumin, photodynamic properties, cytotoxicity in glioblastoma A172 and lung carcinoma A549 cell lines, erythrocytes haemolysis, platelet aggregation, genotoxicity on human peripheral blood mononuclear cells was conducted. Moreover, the dynamic and structural characteristics of C60-Hyp–H2O binary system were obtained using molecular dynamic (MD) method, and size distribution along with ζ-potentials of C60-Hyp associates was measured.",
keywords = "Cytotoxicity, DPPH, Fullerene, Genotoxicity, Haemolysis, HSA, Molecular dynamics, Photobleaching, Platelet aggregation",
author = "Meshcheriakov, {Anatolii A.} and Iurev, {Gleb O.} and Luttsev, {Michail D.} and Podolsky, {Nikita E.} and Ageev, {Sergei V.} and Petrov, {Andrey V.} and Vasina, {Lubov V.} and Solovtsova, {Irina L.} and Sharoyko, {Vladimir V.} and Murin, {Igor V.} and Semenov, {Konstantin N.}",
note = "Funding Information: The work was supported by the Grants of the Russian Foundation for Basic Research ( 19-015-00469 , 19-315-90122 ). Research was performed by using the equipment of the Resource Centre “GeoModel”, Centre for Diagnostics of Functional Materials for Medicine, Pharmacology and Nanoelectronics, Magnetic Resonance Research Centre; computational resources provided by Resource Centre “Computer Centre of SPbU” ( http://cc.spbu.ru ) and Centre for Chemical Analysis and Materials Research of the Research Park of Saint Petersburg State University. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = dec,
doi = "10.1016/j.colsurfb.2020.111338",
language = "English",
volume = "196",
journal = "Colloids and Surfaces B: Biointerfaces",
issn = "0927-7765",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct

AU - Meshcheriakov, Anatolii A.

AU - Iurev, Gleb O.

AU - Luttsev, Michail D.

AU - Podolsky, Nikita E.

AU - Ageev, Sergei V.

AU - Petrov, Andrey V.

AU - Vasina, Lubov V.

AU - Solovtsova, Irina L.

AU - Sharoyko, Vladimir V.

AU - Murin, Igor V.

AU - Semenov, Konstantin N.

N1 - Funding Information: The work was supported by the Grants of the Russian Foundation for Basic Research ( 19-015-00469 , 19-315-90122 ). Research was performed by using the equipment of the Resource Centre “GeoModel”, Centre for Diagnostics of Functional Materials for Medicine, Pharmacology and Nanoelectronics, Magnetic Resonance Research Centre; computational resources provided by Resource Centre “Computer Centre of SPbU” ( http://cc.spbu.ru ) and Centre for Chemical Analysis and Materials Research of the Research Park of Saint Petersburg State University. Publisher Copyright: © 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - Amino acid adducts of light fullerenes have a potential of application in a variety of fields of biomedicine, that is reactive oxygen species scavenging activity, anticancer activity, viruses and bacteria inactivation etc. In this work, the water-soluble C60 fullerene derivative with L-hydroxyproline (C60(C5H9NO3)2, C60-Hyp) was studied. Extensive biomedical investigation of this compound, namely, antiradical activity in the reaction with stable diphenylpicrylhydrazyl radical, the binding to human serum albumin, photodynamic properties, cytotoxicity in glioblastoma A172 and lung carcinoma A549 cell lines, erythrocytes haemolysis, platelet aggregation, genotoxicity on human peripheral blood mononuclear cells was conducted. Moreover, the dynamic and structural characteristics of C60-Hyp–H2O binary system were obtained using molecular dynamic (MD) method, and size distribution along with ζ-potentials of C60-Hyp associates was measured.

AB - Amino acid adducts of light fullerenes have a potential of application in a variety of fields of biomedicine, that is reactive oxygen species scavenging activity, anticancer activity, viruses and bacteria inactivation etc. In this work, the water-soluble C60 fullerene derivative with L-hydroxyproline (C60(C5H9NO3)2, C60-Hyp) was studied. Extensive biomedical investigation of this compound, namely, antiradical activity in the reaction with stable diphenylpicrylhydrazyl radical, the binding to human serum albumin, photodynamic properties, cytotoxicity in glioblastoma A172 and lung carcinoma A549 cell lines, erythrocytes haemolysis, platelet aggregation, genotoxicity on human peripheral blood mononuclear cells was conducted. Moreover, the dynamic and structural characteristics of C60-Hyp–H2O binary system were obtained using molecular dynamic (MD) method, and size distribution along with ζ-potentials of C60-Hyp associates was measured.

KW - Cytotoxicity

KW - DPPH

KW - Fullerene

KW - Genotoxicity

KW - Haemolysis

KW - HSA

KW - Molecular dynamics

KW - Photobleaching

KW - Platelet aggregation

UR - http://www.scopus.com/inward/record.url?scp=85089998332&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/db2f736e-b269-322c-ab3d-02f71a1f0752/

U2 - 10.1016/j.colsurfb.2020.111338

DO - 10.1016/j.colsurfb.2020.111338

M3 - Article

C2 - 32882599

AN - SCOPUS:85089998332

VL - 196

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

M1 - 111338

ER -

ID: 70794397