TY - JOUR

T1 - Pharmacoeconomic and Pharmacoepidemiological Analysis of Changes in the Practice of Perioperative Antibiotic Prophylaxis in a Multi-Specialty Surgical Hospital Based on the Local Real-World Data

AU - Kolbin, A

AU - Velum, I

AU - Balykina, Y

AU - Proskurin, M

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Objectives: The aim of the study was to assess the impact of a new regulation of perioperative antibiotic prophylaxis on the optimization of the use of antimicrobial drugs. Methods: The new schemes take into account the results of screening for the multi-resistant microorganisms: MRSA, MRSCons, VIM, IMP and NDM, KPC, OXA-48, ESBL, AmpC. Data on the antibiotic consumption for the periods before (control) and after (study) the introduction of the new protocol, as well as the data on the length of hospital stay and stay in the intensive care unit (ICU) were analyzed. The assessment of the structure and volume of antibiotic consumption was carried out on the basis of the ACT/DDD methodology. Results: 11,244 out of 13,550 patient case records were studied, 6,461 (58%) of them contained antimicrobial drugs prescriptions. The profiles of interventions were gynecological, oncological, cardiovascular, orthopedic, urological, and endocrinological. ACT/DDD analysis showed a 27% decrease in antibiotic consumption after the introduction of a new protocol. A change in the length of stay in the hospital and in the ICU was observed for the cardiovascular and orthopedic surgery. The analysis revealed a decrease in the cost of drug provision. Conclusions: Changing the antibiotic prophylaxis schemes taking into account the results of screening for the resistant flora leads to a reduction in the consumption of antibiotics and, as a consequence, a reduction in the cost of this group of drugs.

AB - Objectives: The aim of the study was to assess the impact of a new regulation of perioperative antibiotic prophylaxis on the optimization of the use of antimicrobial drugs. Methods: The new schemes take into account the results of screening for the multi-resistant microorganisms: MRSA, MRSCons, VIM, IMP and NDM, KPC, OXA-48, ESBL, AmpC. Data on the antibiotic consumption for the periods before (control) and after (study) the introduction of the new protocol, as well as the data on the length of hospital stay and stay in the intensive care unit (ICU) were analyzed. The assessment of the structure and volume of antibiotic consumption was carried out on the basis of the ACT/DDD methodology. Results: 11,244 out of 13,550 patient case records were studied, 6,461 (58%) of them contained antimicrobial drugs prescriptions. The profiles of interventions were gynecological, oncological, cardiovascular, orthopedic, urological, and endocrinological. ACT/DDD analysis showed a 27% decrease in antibiotic consumption after the introduction of a new protocol. A change in the length of stay in the hospital and in the ICU was observed for the cardiovascular and orthopedic surgery. The analysis revealed a decrease in the cost of drug provision. Conclusions: Changing the antibiotic prophylaxis schemes taking into account the results of screening for the resistant flora leads to a reduction in the consumption of antibiotics and, as a consequence, a reduction in the cost of this group of drugs.

UR - https://www.mendeley.com/catalogue/97b95c64-da30-3249-b5a5-ab837d78cea3/

U2 - 10.1016/j.jval.2022.04.456

DO - 10.1016/j.jval.2022.04.456

M3 - Meeting Abstract

VL - 25

SP - S374

JO - Value in Health

JF - Value in Health

SN - 1098-3015

IS - 7 Suppl

T2 - The Future of HEOR in Patient-Driven Digital Healthcare Systems

Y2 - 17 October 2022

ER -