Research output: Contribution to journal › Article › peer-review
Peculiarities of interactions between the DNA molecule and different isomers and modifications of binuclear coordination compounds of platinum(II). / Bogdanov, A. A.; Kosmotynskaya, Yu V.; Yakovlev, K. I.; Kas'yanenko, N. A.
In: Journal of Structural Chemistry, Vol. 47, No. 1, 01.2006, p. 178-185.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Peculiarities of interactions between the DNA molecule and different isomers and modifications of binuclear coordination compounds of platinum(II)
AU - Bogdanov, A. A.
AU - Kosmotynskaya, Yu V.
AU - Yakovlev, K. I.
AU - Kas'yanenko, N. A.
N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/1
Y1 - 2006/1
N2 - A comparison has been made of conformational changes in the DNA molecule during its interaction in solution with different binuclear coordination compounds of platinum [Pt(NH 3) 2Cl-R-Pt(NH 3) 2Cl]Cl 2 in cis and trans conformations, which contain cytosine, pyrazine, and carboxypyrazine as the common ligand (R). The influence of concentration of the components, and in particular, of ionic strength of the solution on the complexation process was studied. The influence of the nature of the common ligand, and of cis and trans conformations of coordination compounds on the character of their interaction with DNA was considered. A comparison was made between the structures of DNA complexes with mono-and binuclear compounds with the same set of ligands in the platinum coordination sphere.
AB - A comparison has been made of conformational changes in the DNA molecule during its interaction in solution with different binuclear coordination compounds of platinum [Pt(NH 3) 2Cl-R-Pt(NH 3) 2Cl]Cl 2 in cis and trans conformations, which contain cytosine, pyrazine, and carboxypyrazine as the common ligand (R). The influence of concentration of the components, and in particular, of ionic strength of the solution on the complexation process was studied. The influence of the nature of the common ligand, and of cis and trans conformations of coordination compounds on the character of their interaction with DNA was considered. A comparison was made between the structures of DNA complexes with mono-and binuclear compounds with the same set of ligands in the platinum coordination sphere.
KW - Binuclear compounds of Pt(II)
KW - DNA-platinum complex
KW - Platinum coordinate compounds
UR - http://www.scopus.com/inward/record.url?scp=33748975545&partnerID=8YFLogxK
U2 - 10.1007/s10947-006-0284-x
DO - 10.1007/s10947-006-0284-x
M3 - Article
AN - SCOPUS:33748975545
VL - 47
SP - 178
EP - 185
JO - Journal of Structural Chemistry
JF - Journal of Structural Chemistry
SN - 0022-4766
IS - 1
ER -
ID: 73391043