TY - JOUR

T1 - Pattern of taar5 expression in the human brain based on transcriptome datasets analysis

AU - Vaganova, Anastasia N.

AU - Murtazina, Ramilya Z.

AU - Shemyakova, Taisiia S.

AU - Prjibelski, Andrey D.

AU - Katolikova, Nataliia V.

AU - Gainetdinov, Raul R.

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/8/16

Y1 - 2021/8/16

N2 - Trace amine-associated receptors (TAAR) recognize organic compounds, including primary, secondary, and tertiary amines. The TAAR5 receptor is known to be involved in the olfactory sensing of innate socially relevant odors encoded by volatile amines. However, emerging data point to the involvement of TAAR5 in brain functions, particularly in the emotional behaviors mediated by the limbic system which suggests its potential contribution to the pathogenesis of neuropsychiatric diseases. TAAR5 expression was explored in datasets available in the Gene Expression Omnibus, Allen Brain Atlas, and Human Protein Atlas databases. Transcriptomic data demonstrate ubiquitous low TAAR5 expression in the cortical and limbic brain areas, the amygdala and the hippocampus, the nucleus accumbens, the thalamus, the hypothalamus, the basal ganglia, the cerebellum, the substantia nigra, and the white matter. Altered TAAR5 expression is identified in Down syndrome, major depressive disorder, or HIV-associated encephalitis. Taken together, these data indicate that TAAR5 in humans is expressed not only in the olfactory system but also in certain brain structures, including the limbic regions receiving olfactory input and involved in critical brain functions. Thus, TAAR5 can potentially be involved in the pathogenesis of brain disorders and represents a valuable novel target for neuropsychopharmacology.

AB - Trace amine-associated receptors (TAAR) recognize organic compounds, including primary, secondary, and tertiary amines. The TAAR5 receptor is known to be involved in the olfactory sensing of innate socially relevant odors encoded by volatile amines. However, emerging data point to the involvement of TAAR5 in brain functions, particularly in the emotional behaviors mediated by the limbic system which suggests its potential contribution to the pathogenesis of neuropsychiatric diseases. TAAR5 expression was explored in datasets available in the Gene Expression Omnibus, Allen Brain Atlas, and Human Protein Atlas databases. Transcriptomic data demonstrate ubiquitous low TAAR5 expression in the cortical and limbic brain areas, the amygdala and the hippocampus, the nucleus accumbens, the thalamus, the hypothalamus, the basal ganglia, the cerebellum, the substantia nigra, and the white matter. Altered TAAR5 expression is identified in Down syndrome, major depressive disorder, or HIV-associated encephalitis. Taken together, these data indicate that TAAR5 in humans is expressed not only in the olfactory system but also in certain brain structures, including the limbic regions receiving olfactory input and involved in critical brain functions. Thus, TAAR5 can potentially be involved in the pathogenesis of brain disorders and represents a valuable novel target for neuropsychopharmacology.

KW - Brain cortex

KW - Down syndrome

KW - HIV-encephalitis

KW - Human brain

KW - Major depressive disorder

KW - Striatum

KW - TAAR

KW - TAAR5

KW - Trace amine-associated receptor

KW - Trace amines

KW - White matter

KW - brain cortex

KW - TRACE AMINES

KW - trace amines

KW - AMINE-ASSOCIATED RECEPTORS

KW - white matter

KW - human brain

KW - striatum

KW - PACKAGE

KW - GENE-EXPRESSION

KW - VARIANTS

KW - DOPAMINE D1

KW - MESSENGER-RNAS

KW - major depressive disorder

KW - trace amine-associated receptor

KW - DOWN-SYNDROME

KW - DISEASE

KW - NEURONS

UR - http://www.scopus.com/inward/record.url?scp=85112533534&partnerID=8YFLogxK

U2 - 10.3390/ijms22168802

DO - 10.3390/ijms22168802

M3 - Article

AN - SCOPUS:85112533534

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 16

M1 - 8802

ER -