Standard

Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery. / Гейль, Кирилл Константинович; Байкова, Светлана Олеговна; Андоскин, Павел; Шаройко, Владимир Владимирович; Елисеева, Анастасия Александровна; Байков, Сергей Валентинович; Семёнов, Константин Николаевич; Боярский, Вадим Павлович.

In: Inorganics, Vol. 10, No. 12, 247, 07.12.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Гейль, КК, Байкова, СО, Андоскин, П, Шаройко, ВВ, Елисеева, АА, Байков, СВ, Семёнов, КН & Боярский, ВП 2022, 'Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery', Inorganics, vol. 10, no. 12, 247. https://doi.org/10.3390/inorganics10120247

APA

Гейль, К. К., Байкова, С. О., Андоскин, П., Шаройко, В. В., Елисеева, А. А., Байков, С. В., Семёнов, К. Н., & Боярский, В. П. (2022). Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery. Inorganics, 10(12), [247]. https://doi.org/10.3390/inorganics10120247

Vancouver

Гейль КК, Байкова СО, Андоскин П, Шаройко ВВ, Елисеева АА, Байков СВ et al. Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery. Inorganics. 2022 Dec 7;10(12). 247. https://doi.org/10.3390/inorganics10120247

Author

Гейль, Кирилл Константинович ; Байкова, Светлана Олеговна ; Андоскин, Павел ; Шаройко, Владимир Владимирович ; Елисеева, Анастасия Александровна ; Байков, Сергей Валентинович ; Семёнов, Константин Николаевич ; Боярский, Вадим Павлович. / Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery. In: Inorganics. 2022 ; Vol. 10, No. 12.

BibTeX

@article{b17c0bb69d3a4923aee2cacd14e8c82e,
title = "Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery",
abstract = "Metal mediated coupling of isocyanides with substituted N-(pyridine-2-yl) ureas was first used to incorporate privileged biological motifs into platinum metal complexes. We synthesized two palladium(II) and two platinum(II) cyclometallated species with oxadiazole cores. The compounds were isolated in good yields (61–73%) and characterized by high-resolution mass spectrometry and 1H, 13C, and 195Pt NMR spectroscopies. The structures of three complexes were additionally elucidated by X-ray diffraction analysis. These complexes indeed showed cytotoxic activity. The species bearing the 1,3,4-oxadiazole moiety exhibit more potency than the ones with the 1,2,4-oxadiazole ring. Particularly, the cytotoxic effect of both 1,3,4-oxadiazole-based complexes towards T98G cells significantly exceeds the common antitumor metal-drug cisplatin.",
author = "Гейль, {Кирилл Константинович} and Байкова, {Светлана Олеговна} and Павел Андоскин and Шаройко, {Владимир Владимирович} and Елисеева, {Анастасия Александровна} and Байков, {Сергей Валентинович} and Семёнов, {Константин Николаевич} and Боярский, {Вадим Павлович}",
year = "2022",
month = dec,
day = "7",
doi = "10.3390/inorganics10120247",
language = "English",
volume = "10",
journal = "Inorganics",
issn = "2304-6740",
publisher = "MDPI AG",
number = "12",

}

RIS

TY - JOUR

T1 - Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery

AU - Гейль, Кирилл Константинович

AU - Байкова, Светлана Олеговна

AU - Андоскин, Павел

AU - Шаройко, Владимир Владимирович

AU - Елисеева, Анастасия Александровна

AU - Байков, Сергей Валентинович

AU - Семёнов, Константин Николаевич

AU - Боярский, Вадим Павлович

PY - 2022/12/7

Y1 - 2022/12/7

N2 - Metal mediated coupling of isocyanides with substituted N-(pyridine-2-yl) ureas was first used to incorporate privileged biological motifs into platinum metal complexes. We synthesized two palladium(II) and two platinum(II) cyclometallated species with oxadiazole cores. The compounds were isolated in good yields (61–73%) and characterized by high-resolution mass spectrometry and 1H, 13C, and 195Pt NMR spectroscopies. The structures of three complexes were additionally elucidated by X-ray diffraction analysis. These complexes indeed showed cytotoxic activity. The species bearing the 1,3,4-oxadiazole moiety exhibit more potency than the ones with the 1,2,4-oxadiazole ring. Particularly, the cytotoxic effect of both 1,3,4-oxadiazole-based complexes towards T98G cells significantly exceeds the common antitumor metal-drug cisplatin.

AB - Metal mediated coupling of isocyanides with substituted N-(pyridine-2-yl) ureas was first used to incorporate privileged biological motifs into platinum metal complexes. We synthesized two palladium(II) and two platinum(II) cyclometallated species with oxadiazole cores. The compounds were isolated in good yields (61–73%) and characterized by high-resolution mass spectrometry and 1H, 13C, and 195Pt NMR spectroscopies. The structures of three complexes were additionally elucidated by X-ray diffraction analysis. These complexes indeed showed cytotoxic activity. The species bearing the 1,3,4-oxadiazole moiety exhibit more potency than the ones with the 1,2,4-oxadiazole ring. Particularly, the cytotoxic effect of both 1,3,4-oxadiazole-based complexes towards T98G cells significantly exceeds the common antitumor metal-drug cisplatin.

UR - https://www.mdpi.com/2304-6740/10/12/247

UR - https://www.mendeley.com/catalogue/3c1134d1-ef3e-3c4c-91e3-d31ef043c7c7/

U2 - 10.3390/inorganics10120247

DO - 10.3390/inorganics10120247

M3 - Article

VL - 10

JO - Inorganics

JF - Inorganics

SN - 2304-6740

IS - 12

M1 - 247

ER -

ID: 100904777