P298 Thyroid cancer patient’s fertility after radioactive iodine therapy

Standard

P298 Thyroid cancer patient’s fertility after radioactive iodine therapy. / Vabalayte, Kristina; Romanchishen, Anatoly.

In: Archives of Disease in Childhood, Vol. 104, No. Suppl 3, A277, 06.2019.

Research output: Contribution to journal › Meeting Abstract › peer-review

Author

Vabalayte, Kristina ; Romanchishen, Anatoly. / P298 Thyroid cancer patient’s fertility after radioactive iodine therapy. In: Archives of Disease in Childhood. 2019 ; Vol. 104, No. Suppl 3.

BibTeX

@article{2605170b72cf46939aed7921090c2bcd,

title = "P298 Thyroid cancer patient{\textquoteright}s fertility after radioactive iodine therapy",

abstract = "Background: For patients with differentiated thyroid carcinoma (DTC), the effect of radioactive iodine (RAI) therapy on gona-dal and reproductive function is an important consideration. Objective and methods 127 children were operated on thyroid in case of DTC during 1975-2015. 87 pts were treated by RAI (1-13 times). Average age is 15 years (4-18). Histological types of DTC were papillary (69%), follicular (27%), other (4%). Average follow up period is 3 year (2-40). We analyzed effect of therapeutic RAI on sex steroid level; on ovarian function, menses, ovulation in women; sperm in men; future fertility; pregnancy outcomes. Result(s): Early side effects (during 1stweek after RAI) included-nausea and vomiting(29%), sialoadenitis (22%), temporal bone marrow dysfunction (6%). Late side effects included permanent salivary glands' dysfunction (2%), permanent bone marrow dysfunction (4%), lung fibrosis (5%), second tumors - leucosis, breast cancer (4%), fertility disorder (7%). Fertility was analyzed in 78 pts. Sterility (2%), amenorrhea (4%), changes in menstrual period (5%), miscarriage (4%). Conclusion(s): RAI should be prescribed only for indications. Sexual cell should be cryopreserve before RAI.",

author = "Kristina Vabalayte and Anatoly Romanchishen",

year = "2019",

month = jun,

doi = "10.1136/archdischild-2019-epa.648",

language = "русский",

volume = "104",

journal = "Archives of Disease in Childhood",

issn = "0003-9888",

publisher = "BMJ Publishing Group",

number = "Suppl 3",

}

RIS

TY - JOUR

T1 - P298 Thyroid cancer patient’s fertility after radioactive iodine therapy

AU - Vabalayte, Kristina

AU - Romanchishen, Anatoly

PY - 2019/6

Y1 - 2019/6

N2 - Background: For patients with differentiated thyroid carcinoma (DTC), the effect of radioactive iodine (RAI) therapy on gona-dal and reproductive function is an important consideration. Objective and methods 127 children were operated on thyroid in case of DTC during 1975-2015. 87 pts were treated by RAI (1-13 times). Average age is 15 years (4-18). Histological types of DTC were papillary (69%), follicular (27%), other (4%). Average follow up period is 3 year (2-40). We analyzed effect of therapeutic RAI on sex steroid level; on ovarian function, menses, ovulation in women; sperm in men; future fertility; pregnancy outcomes. Result(s): Early side effects (during 1stweek after RAI) included-nausea and vomiting(29%), sialoadenitis (22%), temporal bone marrow dysfunction (6%). Late side effects included permanent salivary glands' dysfunction (2%), permanent bone marrow dysfunction (4%), lung fibrosis (5%), second tumors - leucosis, breast cancer (4%), fertility disorder (7%). Fertility was analyzed in 78 pts. Sterility (2%), amenorrhea (4%), changes in menstrual period (5%), miscarriage (4%). Conclusion(s): RAI should be prescribed only for indications. Sexual cell should be cryopreserve before RAI.

AB - Background: For patients with differentiated thyroid carcinoma (DTC), the effect of radioactive iodine (RAI) therapy on gona-dal and reproductive function is an important consideration. Objective and methods 127 children were operated on thyroid in case of DTC during 1975-2015. 87 pts were treated by RAI (1-13 times). Average age is 15 years (4-18). Histological types of DTC were papillary (69%), follicular (27%), other (4%). Average follow up period is 3 year (2-40). We analyzed effect of therapeutic RAI on sex steroid level; on ovarian function, menses, ovulation in women; sperm in men; future fertility; pregnancy outcomes. Result(s): Early side effects (during 1stweek after RAI) included-nausea and vomiting(29%), sialoadenitis (22%), temporal bone marrow dysfunction (6%). Late side effects included permanent salivary glands' dysfunction (2%), permanent bone marrow dysfunction (4%), lung fibrosis (5%), second tumors - leucosis, breast cancer (4%), fertility disorder (7%). Fertility was analyzed in 78 pts. Sterility (2%), amenorrhea (4%), changes in menstrual period (5%), miscarriage (4%). Conclusion(s): RAI should be prescribed only for indications. Sexual cell should be cryopreserve before RAI.

UR - https://www.mendeley.com/catalogue/b1c746ca-7a3e-3952-acd5-d012b76d292f/

U2 - 10.1136/archdischild-2019-epa.648

DO - 10.1136/archdischild-2019-epa.648

M3 - тезисы

VL - 104

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

IS - Suppl 3

M1 - A277

ER -

ID: 73470620