Oxylipin profiles in plasma of patients with wilson’s disease

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Oxylipin profiles in plasma of patients with wilson’s disease. / Azbukina, Nadezhda V.; Lopachev, Alexander V.; Chistyakov, Dmitry V.; Goriainov, Sergei V.; Astakhova, Alina A.; Poleshuk, Vsevolod V.; Kazanskaya, Rogneda B.; Fedorova, Tatiana N.; Sergeeva, Marina G.

In: Metabolites, Vol. 10, No. 6, 222, 06.2020.

Research output: Contribution to journal › Article › peer-review

Harvard

Azbukina, NV, Lopachev, AV, Chistyakov, DV, Goriainov, SV, Astakhova, AA, Poleshuk, VV, Kazanskaya, RB, Fedorova, TN & Sergeeva, MG 2020, 'Oxylipin profiles in plasma of patients with wilson’s disease', Metabolites, vol. 10, no. 6, 222. https://doi.org/10.3390/metabo10060222

APA

Azbukina, N. V., Lopachev, A. V., Chistyakov, D. V., Goriainov, S. V., Astakhova, A. A., Poleshuk, V. V., Kazanskaya, R. B., Fedorova, T. N., & Sergeeva, M. G. (2020). Oxylipin profiles in plasma of patients with wilson’s disease. Metabolites, 10(6), [222]. https://doi.org/10.3390/metabo10060222

Vancouver

Azbukina NV, Lopachev AV, Chistyakov DV, Goriainov SV, Astakhova AA, Poleshuk VV et al. Oxylipin profiles in plasma of patients with wilson’s disease. Metabolites. 2020 Jun;10(6). 222. https://doi.org/10.3390/metabo10060222

Author

Azbukina, Nadezhda V. ; Lopachev, Alexander V. ; Chistyakov, Dmitry V. ; Goriainov, Sergei V. ; Astakhova, Alina A. ; Poleshuk, Vsevolod V. ; Kazanskaya, Rogneda B. ; Fedorova, Tatiana N. ; Sergeeva, Marina G. / Oxylipin profiles in plasma of patients with wilson’s disease. In: Metabolites. 2020 ; Vol. 10, No. 6.

BibTeX

@article{2f5fc97f27574be381c49ed006e74ecd,

title = "Oxylipin profiles in plasma of patients with wilson{\textquoteright}s disease",

abstract = "Wilson{\textquoteright}s disease (WD) is a rare autosomal recessive metabolic disorder resulting from mutations in the copper-transporting, P-type ATPase gene ATP7B gene, but influences of epigenetics, environment, age, and sex-related factors on the WD phenotype complicate diagnosis and clinical manifestations. Oxylipins, derivatives of omega-3, and omega-6 polyunsaturated fatty acids (PUFAs) are signaling mediators that are deeply involved in innate immunity responses; the regulation of inflammatory responses, including acute and chronic inflammation; and other disturbances related to any system diseases. Therefore, oxylipin profile tests are attractive for the diagnosis of WD. With UPLC-MS/MS lipidomics analysis, we detected 43 oxylipins in the plasma profiles of 39 patients with various clinical manifestations of WD compared with 16 healthy controls (HCs). Analyzing the similarity matrix of oxylipin profiles allowed us to cluster patients into three groups. Analysis of the data by VolcanoPlot and partial least square discriminant analysis (PLS-DA) showed that eight oxylipins and lipids stand for the variance between WD and HCs: eicosapentaenoic acid EPA, oleoylethanolamide OEA, octadecadienoic acids 9-HODE, 9-KODE, 12-hydroxyheptadecatrenoic acid 12-HHT, prostaglandins PGD2, PGE2, and 14,15-dihydroxyeicosatrienoic acids 14,15-DHET. The compounds indicate the involvement of oxidative stress damage, inflammatory processes, and peroxisome proliferator-activated receptor (PPAR) signaling pathways in this disease. The data reveal novel possible therapeutic targets and intervention strategies for treating WD.",

keywords = "COX, CYP450, Lipidomics, LOX, Oxylipins, PUFAs, Wilson{\textquoteright}s disease",

author = "Azbukina, {Nadezhda V.} and Lopachev, {Alexander V.} and Chistyakov, {Dmitry V.} and Goriainov, {Sergei V.} and Astakhova, {Alina A.} and Poleshuk, {Vsevolod V.} and Kazanskaya, {Rogneda B.} and Fedorova, {Tatiana N.} and Sergeeva, {Marina G.}",

note = "Funding Information: Funding: The reported study was funded by RFBR according to the research project № 19-29-01243. Publisher Copyright: {\textcopyright} 2020 by the authors.",

year = "2020",

month = jun,

doi = "10.3390/metabo10060222",

language = "English",

volume = "10",

journal = "Metabolites",

issn = "2218-1989",

publisher = "MDPI AG",

number = "6",

}

RIS

TY - JOUR

T1 - Oxylipin profiles in plasma of patients with wilson’s disease

AU - Azbukina, Nadezhda V.

AU - Lopachev, Alexander V.

AU - Chistyakov, Dmitry V.

AU - Goriainov, Sergei V.

AU - Astakhova, Alina A.

AU - Poleshuk, Vsevolod V.

AU - Kazanskaya, Rogneda B.

AU - Fedorova, Tatiana N.

AU - Sergeeva, Marina G.

PY - 2020/6

Y1 - 2020/6

N2 - Wilson’s disease (WD) is a rare autosomal recessive metabolic disorder resulting from mutations in the copper-transporting, P-type ATPase gene ATP7B gene, but influences of epigenetics, environment, age, and sex-related factors on the WD phenotype complicate diagnosis and clinical manifestations. Oxylipins, derivatives of omega-3, and omega-6 polyunsaturated fatty acids (PUFAs) are signaling mediators that are deeply involved in innate immunity responses; the regulation of inflammatory responses, including acute and chronic inflammation; and other disturbances related to any system diseases. Therefore, oxylipin profile tests are attractive for the diagnosis of WD. With UPLC-MS/MS lipidomics analysis, we detected 43 oxylipins in the plasma profiles of 39 patients with various clinical manifestations of WD compared with 16 healthy controls (HCs). Analyzing the similarity matrix of oxylipin profiles allowed us to cluster patients into three groups. Analysis of the data by VolcanoPlot and partial least square discriminant analysis (PLS-DA) showed that eight oxylipins and lipids stand for the variance between WD and HCs: eicosapentaenoic acid EPA, oleoylethanolamide OEA, octadecadienoic acids 9-HODE, 9-KODE, 12-hydroxyheptadecatrenoic acid 12-HHT, prostaglandins PGD2, PGE2, and 14,15-dihydroxyeicosatrienoic acids 14,15-DHET. The compounds indicate the involvement of oxidative stress damage, inflammatory processes, and peroxisome proliferator-activated receptor (PPAR) signaling pathways in this disease. The data reveal novel possible therapeutic targets and intervention strategies for treating WD.

AB - Wilson’s disease (WD) is a rare autosomal recessive metabolic disorder resulting from mutations in the copper-transporting, P-type ATPase gene ATP7B gene, but influences of epigenetics, environment, age, and sex-related factors on the WD phenotype complicate diagnosis and clinical manifestations. Oxylipins, derivatives of omega-3, and omega-6 polyunsaturated fatty acids (PUFAs) are signaling mediators that are deeply involved in innate immunity responses; the regulation of inflammatory responses, including acute and chronic inflammation; and other disturbances related to any system diseases. Therefore, oxylipin profile tests are attractive for the diagnosis of WD. With UPLC-MS/MS lipidomics analysis, we detected 43 oxylipins in the plasma profiles of 39 patients with various clinical manifestations of WD compared with 16 healthy controls (HCs). Analyzing the similarity matrix of oxylipin profiles allowed us to cluster patients into three groups. Analysis of the data by VolcanoPlot and partial least square discriminant analysis (PLS-DA) showed that eight oxylipins and lipids stand for the variance between WD and HCs: eicosapentaenoic acid EPA, oleoylethanolamide OEA, octadecadienoic acids 9-HODE, 9-KODE, 12-hydroxyheptadecatrenoic acid 12-HHT, prostaglandins PGD2, PGE2, and 14,15-dihydroxyeicosatrienoic acids 14,15-DHET. The compounds indicate the involvement of oxidative stress damage, inflammatory processes, and peroxisome proliferator-activated receptor (PPAR) signaling pathways in this disease. The data reveal novel possible therapeutic targets and intervention strategies for treating WD.

KW - COX

KW - CYP450

KW - Lipidomics

KW - LOX

KW - Oxylipins

KW - PUFAs

KW - Wilson’s disease

UR - http://www.scopus.com/inward/record.url?scp=85085902422&partnerID=8YFLogxK

U2 - 10.3390/metabo10060222

DO - 10.3390/metabo10060222

M3 - Article

VL - 10

JO - Metabolites

JF - Metabolites

SN - 2218-1989

IS - 6

M1 - 222

ER -

ID: 78574995