Osobennosti makrofagal'noi formuly bronkhoal'veoliarnogo smyva u bol'nykh destruktivnym tuberkulezom legkikh. / Lepekha, L. N.; Lovacheva, O. V.; Chernichenko, N. V.; Erokhin, V. V.; Seiliev, A. A.; Volchkov, V. A.; Rozenberg, O. A.
In: Problemy tuberkuleza i boleznei legkikh, No. 12, 2003, p. 17-21.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Osobennosti makrofagal'noi formuly bronkhoal'veoliarnogo smyva u bol'nykh destruktivnym tuberkulezom legkikh.
AU - Lepekha, L. N.
AU - Lovacheva, O. V.
AU - Chernichenko, N. V.
AU - Erokhin, V. V.
AU - Seiliev, A. A.
AU - Volchkov, V. A.
AU - Rozenberg, O. A.
PY - 2003
Y1 - 2003
N2 - The macrophageal elements (ME) of bronchoalveolar lavage were cytologically and electron microscopically studied in 11 patients with active pulmonary tuberculosis who took antituberculous drugs during 3-6 months, which did not yield a significant clinical effect (Group 1) and in 24 patients with the disease who received inhaled C-BL during chemotherapy (Group 2). The drug was administered in a dose of 20 mg by a nebulizer every second day during 4-9 weeks. In Group 1, the high levels of young biosynthesizing (32.08 +/- 0.10) and mature secreting (11.50 +/- 0.70) ME were combined with the lower counts of phagocytizing macrophages (11.50 +/- 0.90). In Group 2, the specific features depended on the duration of C-BL use and after 20-28 inhalations their composition tended to normalize: biosynthesizing (18.30 +/- 1.05), secreting (5.80 +/- 0.95), and phagocytizing (47.20 +/- 1.05). In 19 patients from Group 2, the therapeutic effect was clinically regarded as positive.
AB - The macrophageal elements (ME) of bronchoalveolar lavage were cytologically and electron microscopically studied in 11 patients with active pulmonary tuberculosis who took antituberculous drugs during 3-6 months, which did not yield a significant clinical effect (Group 1) and in 24 patients with the disease who received inhaled C-BL during chemotherapy (Group 2). The drug was administered in a dose of 20 mg by a nebulizer every second day during 4-9 weeks. In Group 1, the high levels of young biosynthesizing (32.08 +/- 0.10) and mature secreting (11.50 +/- 0.70) ME were combined with the lower counts of phagocytizing macrophages (11.50 +/- 0.90). In Group 2, the specific features depended on the duration of C-BL use and after 20-28 inhalations their composition tended to normalize: biosynthesizing (18.30 +/- 1.05), secreting (5.80 +/- 0.95), and phagocytizing (47.20 +/- 1.05). In 19 patients from Group 2, the therapeutic effect was clinically regarded as positive.
UR - http://www.scopus.com/inward/record.url?scp=84921703812&partnerID=8YFLogxK
M3 - статья
C2 - 15004966
AN - SCOPUS:84921703812
SP - 17
EP - 21
JO - ПРОБЛЕМЫ ТУБЕРКУЛЕЗА И БОЛЕЗНЕЙ ЛЕГКИХ
JF - ПРОБЛЕМЫ ТУБЕРКУЛЕЗА И БОЛЕЗНЕЙ ЛЕГКИХ
SN - 1728-2993
IS - 12
ER -
ID: 85031581