Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr (Dm nxf1) gene

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Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr (Dm nxf1) gene. / Mamon, Ludmila ; Ginanova, Viktoria ; Kliver, Sergey ; Toropko, Mariya ; Golubkova, Elena .

In: Biological Communications, Vol. 64, No. 2, 2019, p. 146-157.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{6347c352f4b04a9a8961c06976cf862b,

title = "Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr (Dm nxf1) gene",

abstract = "Analysis of the transcriptomes of different organisms has demonstrated that a single gene can have multiple transcripts. The sources of transcriptional vari-ability are the alternative promoters, polyadenylation sites, splicing, and RNA editing. A comparison of the organisms of different taxa has demonstrated that the complexity of organization during evolution arises not due to an increase in the number of protein-coding genes. The greatest variability of transcripts is specific to the nervous and germinal systems. A variety of mechanisms provid-ing for the complexity of the transcriptome ensures a precise and coordinated regulation of organ-specific functions through a combination of cis-acting el-ements and trans-acting factors. The D. melanogaster sbr (Dm nxf1) gene has proven to be an excellent model for investigating mechanisms potentially lead-ing to the emergence of multiple products with various functions.",

keywords = "alternative polyadenylation, alternative splicing, D. melanogaster, Intron retention, NXF (Nuclear Export Factor), transcriptional variability, alternative polyadenylation, alternative splicing, D. melanogaster, Intron retention, NXF (Nuclear Export Factor), transcriptional variability",

author = "Ludmila Mamon and Viktoria Ginanova and Sergey Kliver and Mariya Toropko and Elena Golubkova",

note = "Mamon, L., Ginanova, V., Kliver, S., Toropko, M., and Golubkova, E. 2019. Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr(Dm nxf1) gene. Bio. Comm. 64(2): 146–157. ",

year = "2019",

language = "English",

volume = "64",

pages = "146--157",

journal = "Biological Communications",

issn = "2542-2154",

publisher = "Издательство Санкт-Петербургского университета",

number = "2",

}

RIS

TY - JOUR

T1 - Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr (Dm nxf1) gene

AU - Mamon, Ludmila

AU - Ginanova, Viktoria

AU - Kliver, Sergey

AU - Toropko, Mariya

AU - Golubkova, Elena

N1 - Mamon, L., Ginanova, V., Kliver, S., Toropko, M., and Golubkova, E. 2019. Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr(Dm nxf1) gene. Bio. Comm. 64(2): 146–157.

PY - 2019

Y1 - 2019

N2 - Analysis of the transcriptomes of different organisms has demonstrated that a single gene can have multiple transcripts. The sources of transcriptional vari-ability are the alternative promoters, polyadenylation sites, splicing, and RNA editing. A comparison of the organisms of different taxa has demonstrated that the complexity of organization during evolution arises not due to an increase in the number of protein-coding genes. The greatest variability of transcripts is specific to the nervous and germinal systems. A variety of mechanisms provid-ing for the complexity of the transcriptome ensures a precise and coordinated regulation of organ-specific functions through a combination of cis-acting el-ements and trans-acting factors. The D. melanogaster sbr (Dm nxf1) gene has proven to be an excellent model for investigating mechanisms potentially lead-ing to the emergence of multiple products with various functions.

AB - Analysis of the transcriptomes of different organisms has demonstrated that a single gene can have multiple transcripts. The sources of transcriptional vari-ability are the alternative promoters, polyadenylation sites, splicing, and RNA editing. A comparison of the organisms of different taxa has demonstrated that the complexity of organization during evolution arises not due to an increase in the number of protein-coding genes. The greatest variability of transcripts is specific to the nervous and germinal systems. A variety of mechanisms provid-ing for the complexity of the transcriptome ensures a precise and coordinated regulation of organ-specific functions through a combination of cis-acting el-ements and trans-acting factors. The D. melanogaster sbr (Dm nxf1) gene has proven to be an excellent model for investigating mechanisms potentially lead-ing to the emergence of multiple products with various functions.

KW - alternative polyadenylation

KW - alternative splicing

KW - D. melanogaster

KW - Intron retention

KW - NXF (Nuclear Export Factor)

KW - transcriptional variability

KW - alternative polyadenylation

KW - alternative splicing

KW - D. melanogaster

KW - Intron retention

KW - NXF (Nuclear Export Factor)

KW - transcriptional variability

UR - https://biocomm.spbu.ru/article/view/5037/4593

UR - https://elibrary.ru/item.asp?id=39239061

M3 - Article

VL - 64

SP - 146

EP - 157

JO - Biological Communications

JF - Biological Communications

SN - 2542-2154

IS - 2

ER -

ID: 50674092