Research output: Contribution to journal › Article › peer-review
Optogenetics : Applications in neurobiology. / Mikhailova, Maria; Deal, Alex; Budygin, Evgeny; Gainetdinov, Raul.
In: Biological Communications, Vol. 62, No. 4, 2017, p. 261-271.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Optogenetics
T2 - Applications in neurobiology
AU - Mikhailova, Maria
AU - Deal, Alex
AU - Budygin, Evgeny
AU - Gainetdinov, Raul
N1 - Publisher Copyright: © 2017 Mikhailova.
PY - 2017
Y1 - 2017
N2 - Commonly used neuromodulation techniques such as electrical stimulation or pharmacologic intervention have some technical limitations that preclude dissecting particular cell- or pathway-specific functions in the brain, which is composed of billions of neurons. An advancement of molecular genetics techniques has provided a novel method in neuroscience called optogenetics. Optogenetics uses a combination of genetic and optical methods that provide a means to, with great temporal precision, experimentally control the activation or suppression of specific neuronal sub-populations in heterogeneous brain regions where multiple neuronal subtypes exist; this approach can be performed even on freely moving animals. Thus, this tool can uniquely assist in establishing causality between the disorder and the underlying pathology. Ongoing exploration of pathological mechanisms in various animal models of neuropsychiatric disorders with precise tools such as optogenetics can provide significant advances in the development of more focused approaches to treatment of these disorders. Here, we selectively highlight the major advancements gained by the use of optogenetic tools to uncover at circuit levels mechanisms relevant to neuropsychiatric disorders.
AB - Commonly used neuromodulation techniques such as electrical stimulation or pharmacologic intervention have some technical limitations that preclude dissecting particular cell- or pathway-specific functions in the brain, which is composed of billions of neurons. An advancement of molecular genetics techniques has provided a novel method in neuroscience called optogenetics. Optogenetics uses a combination of genetic and optical methods that provide a means to, with great temporal precision, experimentally control the activation or suppression of specific neuronal sub-populations in heterogeneous brain regions where multiple neuronal subtypes exist; this approach can be performed even on freely moving animals. Thus, this tool can uniquely assist in establishing causality between the disorder and the underlying pathology. Ongoing exploration of pathological mechanisms in various animal models of neuropsychiatric disorders with precise tools such as optogenetics can provide significant advances in the development of more focused approaches to treatment of these disorders. Here, we selectively highlight the major advancements gained by the use of optogenetic tools to uncover at circuit levels mechanisms relevant to neuropsychiatric disorders.
KW - Addiction
KW - Alzheimer’s disease
KW - Depression
KW - Neuropsychiatric disorders
KW - Opsin
KW - Optogenetics
KW - Parkinson’s disease
KW - Schizophrenia
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=85063285815&partnerID=8YFLogxK
U2 - 10.21638/11701/spbu03.2017.405
DO - 10.21638/11701/spbu03.2017.405
M3 - Article
AN - SCOPUS:85063285815
VL - 62
SP - 261
EP - 271
JO - Biological Communications
JF - Biological Communications
SN - 2542-2154
IS - 4
ER -
ID: 87889038