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One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles. / Kopoleva, Elena; Lebedev, Maksim D.; Postovalova, Alisa; Rogova, Anna; Fatkhutdinova, Landysh; Epifanovskaya, Olga; Goncharenko, Alexander A.; Kremleva, Arina V.; Domracheva, Nadezhda; Bukatin, Anton S.; Muslimov, Albert R.; Koroleva, Aleksandra; Zhizhin, Evgeniy V.; Lepik, Kirill V.; Timin, Alexander S.; Peltek, Oleksii; Zyuzin, Mikhail V.

In: Nano Letters, Vol. 23, No. 23, 21.11.2023, p. 10811-10820.

Research output: Contribution to journal › Article › peer-review

Harvard

Kopoleva, E, Lebedev, MD, Postovalova, A, Rogova, A, Fatkhutdinova, L, Epifanovskaya, O, Goncharenko, AA, Kremleva, AV, Domracheva, N, Bukatin, AS, Muslimov, AR, Koroleva, A, Zhizhin, EV, Lepik, KV, Timin, AS, Peltek, O & Zyuzin, MV 2023, 'One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles', Nano Letters, vol. 23, no. 23, pp. 10811-10820. https://doi.org/10.1021/acs.nanolett.3c02933, https://doi.org/10.1021/acs.nanolett.3c02933

APA

Kopoleva, E., Lebedev, M. D., Postovalova, A., Rogova, A., Fatkhutdinova, L., Epifanovskaya, O., Goncharenko, A. A., Kremleva, A. V., Domracheva, N., Bukatin, A. S., Muslimov, A. R., Koroleva, A., Zhizhin, E. V., Lepik, K. V., Timin, A. S., Peltek, O., & Zyuzin, M. V. (2023). One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles. Nano Letters, 23(23), 10811-10820. https://doi.org/10.1021/acs.nanolett.3c02933, https://doi.org/10.1021/acs.nanolett.3c02933

Vancouver

Kopoleva E, Lebedev MD, Postovalova A, Rogova A, Fatkhutdinova L, Epifanovskaya O et al. One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles. Nano Letters. 2023 Nov 21;23(23):10811-10820. https://doi.org/10.1021/acs.nanolett.3c02933, https://doi.org/10.1021/acs.nanolett.3c02933

Author

Kopoleva, Elena ; Lebedev, Maksim D. ; Postovalova, Alisa ; Rogova, Anna ; Fatkhutdinova, Landysh ; Epifanovskaya, Olga ; Goncharenko, Alexander A. ; Kremleva, Arina V. ; Domracheva, Nadezhda ; Bukatin, Anton S. ; Muslimov, Albert R. ; Koroleva, Aleksandra ; Zhizhin, Evgeniy V. ; Lepik, Kirill V. ; Timin, Alexander S. ; Peltek, Oleksii ; Zyuzin, Mikhail V. / One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles. In: Nano Letters. 2023 ; Vol. 23, No. 23. pp. 10811-10820.

BibTeX

@article{ec904c993b7d48f5bb7f83bf67d894a9,
title = "One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles",
abstract = "Redox-responsive drug delivery systems present a promising avenue for drug delivery due to their ability to leverage the unique redox environment within tumor cells. In this work, we describe a facile and cost-effective one-pot synthesis method for a redox-responsive delivery system based on novel trithiocyanuric acid (TTCA) nanoparticles (NPs). We conduct a thorough investigation of the impact of various synthesis parameters on the morphology, stability, and loading capacity of these NPs. The great drug delivery potential of the system is further demonstrated in vitro and in vivo by using doxorubicin as a model drug. The developed TTCA-PEG NPs show great drug delivery efficiency with minimal toxicity on their own both in vivo and in vitro. The simplicity of this synthesis, along with the promising characteristics of TTCA-PEG NPs, paves the way for new opportunities in the further development of redox-responsive drug delivery systems based on TTCA.",
keywords = "drug delivery, glutathione-responsive nanoparticles, redox-responsive nanoparticles, trithiocyanuric acid",
author = "Elena Kopoleva and Lebedev, {Maksim D.} and Alisa Postovalova and Anna Rogova and Landysh Fatkhutdinova and Olga Epifanovskaya and Goncharenko, {Alexander A.} and Kremleva, {Arina V.} and Nadezhda Domracheva and Bukatin, {Anton S.} and Muslimov, {Albert R.} and Aleksandra Koroleva and Zhizhin, {Evgeniy V.} and Lepik, {Kirill V.} and Timin, {Alexander S.} and Oleksii Peltek and Zyuzin, {Mikhail V.}",
note = "PMID: 37988557",
year = "2023",
month = nov,
day = "21",
doi = "10.1021/acs.nanolett.3c02933",
language = "English",
volume = "23",
pages = "10811--10820",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "23",

}

RIS

TY - JOUR

T1 - One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles

AU - Kopoleva, Elena

AU - Lebedev, Maksim D.

AU - Postovalova, Alisa

AU - Rogova, Anna

AU - Fatkhutdinova, Landysh

AU - Epifanovskaya, Olga

AU - Goncharenko, Alexander A.

AU - Kremleva, Arina V.

AU - Domracheva, Nadezhda

AU - Bukatin, Anton S.

AU - Muslimov, Albert R.

AU - Koroleva, Aleksandra

AU - Zhizhin, Evgeniy V.

AU - Lepik, Kirill V.

AU - Timin, Alexander S.

AU - Peltek, Oleksii

AU - Zyuzin, Mikhail V.

N1 - PMID: 37988557

PY - 2023/11/21

Y1 - 2023/11/21

N2 - Redox-responsive drug delivery systems present a promising avenue for drug delivery due to their ability to leverage the unique redox environment within tumor cells. In this work, we describe a facile and cost-effective one-pot synthesis method for a redox-responsive delivery system based on novel trithiocyanuric acid (TTCA) nanoparticles (NPs). We conduct a thorough investigation of the impact of various synthesis parameters on the morphology, stability, and loading capacity of these NPs. The great drug delivery potential of the system is further demonstrated in vitro and in vivo by using doxorubicin as a model drug. The developed TTCA-PEG NPs show great drug delivery efficiency with minimal toxicity on their own both in vivo and in vitro. The simplicity of this synthesis, along with the promising characteristics of TTCA-PEG NPs, paves the way for new opportunities in the further development of redox-responsive drug delivery systems based on TTCA.

AB - Redox-responsive drug delivery systems present a promising avenue for drug delivery due to their ability to leverage the unique redox environment within tumor cells. In this work, we describe a facile and cost-effective one-pot synthesis method for a redox-responsive delivery system based on novel trithiocyanuric acid (TTCA) nanoparticles (NPs). We conduct a thorough investigation of the impact of various synthesis parameters on the morphology, stability, and loading capacity of these NPs. The great drug delivery potential of the system is further demonstrated in vitro and in vivo by using doxorubicin as a model drug. The developed TTCA-PEG NPs show great drug delivery efficiency with minimal toxicity on their own both in vivo and in vitro. The simplicity of this synthesis, along with the promising characteristics of TTCA-PEG NPs, paves the way for new opportunities in the further development of redox-responsive drug delivery systems based on TTCA.

KW - drug delivery

KW - glutathione-responsive nanoparticles

KW - redox-responsive nanoparticles

KW - trithiocyanuric acid

UR - https://www.mendeley.com/catalogue/d577cce9-eef1-3699-9dee-c96de82f697e/

U2 - 10.1021/acs.nanolett.3c02933

DO - 10.1021/acs.nanolett.3c02933

M3 - Article

VL - 23

SP - 10811

EP - 10820

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

IS - 23

ER -

ID: 114873491