Numerical simulations have been performed to estimate sensitivity of ozone fluxes to the impact of mesoscale orographic gravity waves (OGWs) in the middle atmosphere at different phases of simulated stratospheric warming (SW) events during boreal winter. The numerical model of general circulation of the middle and upper atmosphere (MUAM) with implemented OGW parameterization has been used. The simulations demonstrate a weakening of the vertical ozone fluxes during and after simulated SW compared to the time intervals before SW, which corresponds to the changes in meridional mean circulation. The most significant differences in ozone fluxes due to OGW effects are obtained in the Northern Hemisphere. These differences are up to 20% at middle latitudes and may reach 100% at high latitudes. The results indicate a strong sensitivity of the meridional circulation and hence, the ozone fluxes to the influence of OGWs at different phases of simulated SWs.