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Novel non-covalent conjugate based on graphene oxide and alkylating agent from 1,3,5-triazine class. / Sharoyko, Vladimir V. ; Semenov, Konstantin N. ; Mikolaichuk, Olga V.; Shemchuk, Olga S. ; Abdelhali, Abdelsattar O. E. ; Potanin, Artem A. ; Luttsev, Michail D. ; Daler R. Dadajanov; Shasherina, Anna Yu. ; Petrov, Andrey V. ; Murin, Igor V. ; Maystrenko, Dmitriy N.; Molchanov, Oleg E. ; Vartanyan, T.A.

In: Journal of Molecular Liquids, Vol. 372, 121203, 15.02.2023.

Research output: Contribution to journal › Article › peer-review

Harvard

Sharoyko, VV, Semenov, KN, Mikolaichuk, OV, Shemchuk, OS, Abdelhali, AOE, Potanin, AA, Luttsev, MD, Daler R. Dadajanov, Shasherina, AY, Petrov, AV, Murin, IV, Maystrenko, DN, Molchanov, OE & Vartanyan, TA 2023, 'Novel non-covalent conjugate based on graphene oxide and alkylating agent from 1,3,5-triazine class', Journal of Molecular Liquids, vol. 372, 121203. https://doi.org/10.1016/j.molliq.2023.121203

APA

Sharoyko, V. V., Semenov, K. N., Mikolaichuk, O. V., Shemchuk, O. S., Abdelhali, A. O. E., Potanin, A. A., Luttsev, M. D., Daler R. Dadajanov, Shasherina, A. Y., Petrov, A. V., Murin, I. V., Maystrenko, D. N., Molchanov, O. E., & Vartanyan, T. A. (2023). Novel non-covalent conjugate based on graphene oxide and alkylating agent from 1,3,5-triazine class. Journal of Molecular Liquids, 372, [121203]. https://doi.org/10.1016/j.molliq.2023.121203

Vancouver

Sharoyko VV, Semenov KN, Mikolaichuk OV, Shemchuk OS, Abdelhali AOE, Potanin AA et al. Novel non-covalent conjugate based on graphene oxide and alkylating agent from 1,3,5-triazine class. Journal of Molecular Liquids. 2023 Feb 15;372. 121203. https://doi.org/10.1016/j.molliq.2023.121203

Author

Sharoyko, Vladimir V. ; Semenov, Konstantin N. ; Mikolaichuk, Olga V. ; Shemchuk, Olga S. ; Abdelhali, Abdelsattar O. E. ; Potanin, Artem A. ; Luttsev, Michail D. ; Daler R. Dadajanov ; Shasherina, Anna Yu. ; Petrov, Andrey V. ; Murin, Igor V. ; Maystrenko, Dmitriy N. ; Molchanov, Oleg E. ; Vartanyan, T.A. / Novel non-covalent conjugate based on graphene oxide and alkylating agent from 1,3,5-triazine class. In: Journal of Molecular Liquids. 2023 ; Vol. 372.

BibTeX

@article{c2fc4a49c6ae4b42b1dedcfdd0792f8c,
title = "Novel non-covalent conjugate based on graphene oxide and alkylating agent from 1,3,5-triazine class",
abstract = "One of the ways to increase the specificity and biocompatibility of cytostatic drugs is the creation of conjugates of drugs with graphene oxide. Graphene and its oxidized form - graphene oxide (GO) - have become new promising materials in the field of nanomedicine due to its reactive and developed surface that can be subjected to covalent and non-covalent functionalization, which allows provide the immobilization of drugs. This article is devoted to a new method for the synthesis, identification and study of the biocompatibility of a non-covalent conjugate based on GO and an alkylating agent based on 1,3,5-triazine. The conjugate is hemocompatible, exhibit antioxidant activity in the model reaction with DPPH, Radachlorin and photoinduced hemolysis, has dose-dependent genotoxicity, and also exhibit cytotoxicity towards cell lines A549, PANC-1 and HeLa.",
keywords = "antioxidant activity, cytotoxicity, hemocompatibility, graphene oxide, Hemocompatibility, Antioxidant activity, Genotoxicity, Cytotoxicity, 1,3,5-triazine, Graphene oxide",
author = "Sharoyko, {Vladimir V.} and Semenov, {Konstantin N.} and Mikolaichuk, {Olga V.} and Shemchuk, {Olga S.} and Abdelhali, {Abdelsattar O. E.} and Potanin, {Artem A.} and Luttsev, {Michail D.} and {Daler R. Dadajanov} and Shasherina, {Anna Yu.} and Petrov, {Andrey V.} and Murin, {Igor V.} and Maystrenko, {Dmitriy N.} and Molchanov, {Oleg E.} and T.A. Vartanyan",
year = "2023",
month = feb,
day = "15",
doi = "10.1016/j.molliq.2023.121203",
language = "English",
volume = "372",
journal = "Journal of Molecular Liquids",
issn = "0167-7322",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Novel non-covalent conjugate based on graphene oxide and alkylating agent from 1,3,5-triazine class

AU - Sharoyko, Vladimir V.

AU - Semenov, Konstantin N.

AU - Mikolaichuk, Olga V.

AU - Shemchuk, Olga S.

AU - Abdelhali, Abdelsattar O. E.

AU - Potanin, Artem A.

AU - Luttsev, Michail D.

AU - Daler R. Dadajanov, null

AU - Shasherina, Anna Yu.

AU - Petrov, Andrey V.

AU - Murin, Igor V.

AU - Maystrenko, Dmitriy N.

AU - Molchanov, Oleg E.

AU - Vartanyan, T.A.

PY - 2023/2/15

Y1 - 2023/2/15

N2 - One of the ways to increase the specificity and biocompatibility of cytostatic drugs is the creation of conjugates of drugs with graphene oxide. Graphene and its oxidized form - graphene oxide (GO) - have become new promising materials in the field of nanomedicine due to its reactive and developed surface that can be subjected to covalent and non-covalent functionalization, which allows provide the immobilization of drugs. This article is devoted to a new method for the synthesis, identification and study of the biocompatibility of a non-covalent conjugate based on GO and an alkylating agent based on 1,3,5-triazine. The conjugate is hemocompatible, exhibit antioxidant activity in the model reaction with DPPH, Radachlorin and photoinduced hemolysis, has dose-dependent genotoxicity, and also exhibit cytotoxicity towards cell lines A549, PANC-1 and HeLa.

AB - One of the ways to increase the specificity and biocompatibility of cytostatic drugs is the creation of conjugates of drugs with graphene oxide. Graphene and its oxidized form - graphene oxide (GO) - have become new promising materials in the field of nanomedicine due to its reactive and developed surface that can be subjected to covalent and non-covalent functionalization, which allows provide the immobilization of drugs. This article is devoted to a new method for the synthesis, identification and study of the biocompatibility of a non-covalent conjugate based on GO and an alkylating agent based on 1,3,5-triazine. The conjugate is hemocompatible, exhibit antioxidant activity in the model reaction with DPPH, Radachlorin and photoinduced hemolysis, has dose-dependent genotoxicity, and also exhibit cytotoxicity towards cell lines A549, PANC-1 and HeLa.

KW - antioxidant activity

KW - cytotoxicity

KW - hemocompatibility

KW - graphene oxide

KW - Hemocompatibility

KW - Antioxidant activity

KW - Genotoxicity

KW - Cytotoxicity

KW - 1,3,5-triazine

KW - Graphene oxide

UR - https://www.mendeley.com/catalogue/f0b554d5-2170-3ce2-8662-fc781a90877b/

U2 - 10.1016/j.molliq.2023.121203

DO - 10.1016/j.molliq.2023.121203

M3 - Article

VL - 372

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

SN - 0167-7322

M1 - 121203

ER -

ID: 100670874