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Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications. / Shtykalova, Sofia; Deviatkin , Dmitriy ; Freund, Svetlana; Egorova, Anna ; Kiselev, Anton .

In: Life, Vol. 13, No. 4, 903, 29.03.2023.

Research output: Contribution to journal › Article › peer-review

Harvard

Shtykalova, S, Deviatkin , D, Freund, S, Egorova, A & Kiselev, A 2023, 'Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications', Life, vol. 13, no. 4, 903.

APA

Shtykalova, S., Deviatkin , D., Freund, S., Egorova, A., & Kiselev, A. (2023). Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications. Life, 13(4), [903].

Vancouver

Shtykalova S, Deviatkin D, Freund S, Egorova A, Kiselev A. Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications. Life. 2023 Mar 29;13(4). 903.

Author

Shtykalova, Sofia ; Deviatkin , Dmitriy ; Freund, Svetlana ; Egorova, Anna ; Kiselev, Anton . / Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications. In: Life. 2023 ; Vol. 13, No. 4.

BibTeX

@article{da9517e13a494936a4c1047006d3c60e,
title = "Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications",
abstract = "Over the past decades, non-viral DNA and RNA delivery systems have been intensively studied as an alternative to viral vectors. Despite the most significant advantage over viruses, such as the lack of immunogenicity and cytotoxicity, the widespread use of non-viral carriers in clinical practice is still limited due to the insufficient efficacy associated with the difficulties of overcoming extracellular and intracellular barriers. Overcoming barriers by non-viral carriers is facilitated by their chemical structure, surface charge, as well as developed modifications. Currently, there are many different forms of non-viral carriers for various applications. This review aimed to summarize recent developments based on the essential requirements for non-viral carriers for gene therapy.",
keywords = "non-viral carriers, gene delivery, endocytosis, polyplexes, LIPOSOMES, peptide-based carriers, exosomes, microvesicles, nanomaterials",
author = "Sofia Shtykalova and Dmitriy Deviatkin and Svetlana Freund and Anna Egorova and Anton Kiselev",
note = "Shtykalova, S.; Deviatkin, D.; Freund, S.; Egorova, A.; Kiselev, A. Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications. Life 2023, 13, 903. https://doi.org/10.3390/life13040903",
year = "2023",
month = mar,
day = "29",
language = "English",
volume = "13",
journal = "Life",
issn = "0024-3019",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications

AU - Shtykalova, Sofia

AU - Deviatkin , Dmitriy

AU - Freund, Svetlana

AU - Egorova, Anna

AU - Kiselev, Anton

N1 - Shtykalova, S.; Deviatkin, D.; Freund, S.; Egorova, A.; Kiselev, A. Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications. Life 2023, 13, 903. https://doi.org/10.3390/life13040903

PY - 2023/3/29

Y1 - 2023/3/29

N2 - Over the past decades, non-viral DNA and RNA delivery systems have been intensively studied as an alternative to viral vectors. Despite the most significant advantage over viruses, such as the lack of immunogenicity and cytotoxicity, the widespread use of non-viral carriers in clinical practice is still limited due to the insufficient efficacy associated with the difficulties of overcoming extracellular and intracellular barriers. Overcoming barriers by non-viral carriers is facilitated by their chemical structure, surface charge, as well as developed modifications. Currently, there are many different forms of non-viral carriers for various applications. This review aimed to summarize recent developments based on the essential requirements for non-viral carriers for gene therapy.

AB - Over the past decades, non-viral DNA and RNA delivery systems have been intensively studied as an alternative to viral vectors. Despite the most significant advantage over viruses, such as the lack of immunogenicity and cytotoxicity, the widespread use of non-viral carriers in clinical practice is still limited due to the insufficient efficacy associated with the difficulties of overcoming extracellular and intracellular barriers. Overcoming barriers by non-viral carriers is facilitated by their chemical structure, surface charge, as well as developed modifications. Currently, there are many different forms of non-viral carriers for various applications. This review aimed to summarize recent developments based on the essential requirements for non-viral carriers for gene therapy.

KW - non-viral carriers

KW - gene delivery

KW - endocytosis

KW - polyplexes

KW - LIPOSOMES

KW - peptide-based carriers

KW - exosomes

KW - microvesicles

KW - nanomaterials

UR - https://www.mdpi.com/2075-1729/13/4/903

M3 - Article

VL - 13

JO - Life

JF - Life

SN - 0024-3019

IS - 4

M1 - 903

ER -

ID: 106483333