We report the results of our studying the fast line-profile variability (LPV) in spectra of bright OB stars. Spectral and spectropolarimetric observations of 15 OB stars were made during the last ten years in the framework of the program of searching for the regular and stochastic LPV in spectra of OB stars and their magnetic fields. The spectra were obtained using the 6-m telescope of the Special Astronomical Observatory (SAO, Russia) and the 1.8-m telescope of the Bohyunsan Optical Astronomy Observatory (BOAO, Korea). For all studied stars we detected regular LPV connected with non-radial pulsation (NRP) and induced by the rotation of the large-scale structures in the stellar wind. We propose that the NRP are a trigger of the formation of the large-scale structures in the stellar wind. Results of searching for the polarimetric line profile variability (pLPV) in the spectra of OB stars are also reported. We find that the pattern of LPV can differ for the left and right polarized components of stellar radiati