Research output: Contribution to journal › Review article › peer-review
Noninvasive Diagnostics of Renal Amyloidosis: Current State and Perspectives. / Федотов, Сергей Александрович; Храброва, Мария Сергеевна; Анпилова, Анастасия Олеговна; Добронравов, Владимир Александрович; Рубель, Александр Анатольевич.
In: International Journal of Molecular Sciences, Vol. 23, No. 20, 12662, 21.10.2022.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Noninvasive Diagnostics of Renal Amyloidosis: Current State and Perspectives
AU - Федотов, Сергей Александрович
AU - Храброва, Мария Сергеевна
AU - Анпилова, Анастасия Олеговна
AU - Добронравов, Владимир Александрович
AU - Рубель, Александр Анатольевич
N1 - Publisher Copyright: © 2022 by the authors.
PY - 2022/10/21
Y1 - 2022/10/21
N2 - Amyloidoses is a group of diseases characterized by the accumulation of abnormal proteins (called amyloids) in different organs and tissues. For systemic amyloidoses, the disease is related to increased levels and/or abnormal synthesis of certain proteins in the organism due to pathological processes, e.g., monoclonal gammopathy and chronic inflammation in rheumatic arthritis. Treatment of amyloidoses is focused on reducing amyloidogenic protein production and inhibition of its aggregation. Therapeutic approaches critically depend on the type of amyloidosis, which underlines the importance of early differential diagnostics. In fact, the most accurate diagnostics of amyloidosis and its type requires analysis of a biopsy specimen from the disease-affected organ. However, absence of specific symptoms of amyloidosis and the invasive nature of biomaterial sampling causes the late diagnostics of these diseases, which leads to a delayed treatment, and significantly reduces its efficacy and patient survival. The establishment of noninvasive diagnostic methods and discovery of specific amyloidosis markers are essential for disease detection and identification of its type at earlier stages, which enables timely and targeted treatment. This review focuses on current approaches to the diagnostics of amyloidoses, primarily with renal involvement, and research perspectives in order to design new specific tests for early diagnosis.
AB - Amyloidoses is a group of diseases characterized by the accumulation of abnormal proteins (called amyloids) in different organs and tissues. For systemic amyloidoses, the disease is related to increased levels and/or abnormal synthesis of certain proteins in the organism due to pathological processes, e.g., monoclonal gammopathy and chronic inflammation in rheumatic arthritis. Treatment of amyloidoses is focused on reducing amyloidogenic protein production and inhibition of its aggregation. Therapeutic approaches critically depend on the type of amyloidosis, which underlines the importance of early differential diagnostics. In fact, the most accurate diagnostics of amyloidosis and its type requires analysis of a biopsy specimen from the disease-affected organ. However, absence of specific symptoms of amyloidosis and the invasive nature of biomaterial sampling causes the late diagnostics of these diseases, which leads to a delayed treatment, and significantly reduces its efficacy and patient survival. The establishment of noninvasive diagnostic methods and discovery of specific amyloidosis markers are essential for disease detection and identification of its type at earlier stages, which enables timely and targeted treatment. This review focuses on current approaches to the diagnostics of amyloidoses, primarily with renal involvement, and research perspectives in order to design new specific tests for early diagnosis.
KW - protein aggregation
KW - amyloids
KW - early diagnostics
KW - proteinuria
KW - serum
KW - chronic kidney disease
KW - kidney biopsy
KW - seeding
KW - Humans
KW - Amyloidosis/metabolism
KW - Amyloid/metabolism
KW - Immunoglobulin Light-chain Amyloidosis/diagnosis
KW - Amyloidogenic Proteins
KW - Biocompatible Materials
KW - chronic kidney disease
KW - kidney biopsy
KW - proteinuria
KW - amyloids
KW - seeding
KW - protein aggregation
KW - serum
KW - early diagnostics
UR - http://www.scopus.com/inward/record.url?scp=85140809535&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/5424752b-368e-3983-bfcb-dc9b19f3edfa/
U2 - 10.3390/ijms232012662
DO - 10.3390/ijms232012662
M3 - Review article
C2 - 36293523
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1422-0067
IS - 20
M1 - 12662
ER -
ID: 99571119